Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.57 |
| ▸ | RHEB | Q15382 | 1/20 | 0.53 |
| ▸ | SCD | O00767 | 9/20 | 0.53 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.52 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | FADS1 | O60427 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1842216 | 0.82 | PKN1 (0.59) | RHEBNPBWR1PKN1PKN2MEN1 | |
| SCHEMBL11021893 | 0.80 | ATR (0.44) | ATRSCDNPBWR1 | |
| SCHEMBL10765448 | 0.80 | ATR (0.44) | ATRSCDNPBWR1 | |
| SCHEMBL19994470 | 0.80 | RHEB (0.59) | ATRRHEBNPBWR1PKN1PKN2 | |
| SCHEMBL8412123 | 0.80 | RHEB (0.59) | RHEBSCDNPBWR1PKN1PKN2 | |
| SCHEMBL1842081 | 0.80 | RHEB (0.59) | RHEBPKN1PKN2MEN1NPC1 | |
| SCHEMBL3333407 | 0.80 | RHEB (0.68) | RHEBNPBWR1PKN1PKN2MEN1 | |
| SCHEMBL19994459 | 0.80 | NPC1 (0.61) | RHEBNPBWR1PKN1PKN2MEN1 | |
| SCHEMBL30343718 | 0.80 | NPC1 (0.61) | RHEBNPBWR1PKN1PKN2MEN1 | |
| SCHEMBL10759909 | 0.80 | RHEB (0.53) | ATRRHEBPKN1PKN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209707-A2 | 2-Aryl imidazoles, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-01-28 | — | — | EP | disclosed |