Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 3/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021898 | 0.91 | ATR (0.53) | ATRCA12CA1CA2CA9 | |
| SCHEMBL10765448 | 0.91 | ATR (0.44) | ATRMAPK10CYP11B1CYP11B2CDK4 | |
| SCHEMBL11020313 | 0.90 | CA2 (0.54) | ATRMAPK10CA12CA1CA2 | |
| SCHEMBL10763275 | 0.89 | MAPK10 (0.42) | MAPK10CA12CA1CA2CA9 | |
| SCHEMBL11016112 | 0.89 | SCN9A (0.42) | MAPK10CA12CA1CA2CA9 | |
| SCHEMBL11022213 | 0.89 | ATR (0.44) | ATRCYP11B1CYP11B2NPBWR1PDE5A | |
| SCHEMBL11018857 | 0.89 | MAPT (0.44) | ATRMAPK10CA12CA1CA2 | |
| SCHEMBL11018071 | 0.87 | CYP2C9 (0.47) | ATRMAPK10CA12CA1CA2 | |
| SCHEMBL10744974 | 0.85 | MAPK10 (0.42) | ATRMAPK10CA12CA1CA2 | |
| SCHEMBL11021552 | 0.84 | L3MBTL1 (0.47) | MAPK10CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | claimed |
| EP-0148431-A1 | Benzimidazoles, their preparation, and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-07-17 | — | — | EP | disclosed |