Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.39 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SCD | O00767 | 3/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021893 | 0.91 | ATR (0.44) | ATRMAPK10CDK4CCNA2CCND1 | |
| SCHEMBL11021898 | 0.83 | ATR (0.53) | ATRCDK4CCNA2CCND1CDK2 | |
| SCHEMBL11022213 | 0.82 | ATR (0.44) | ATRNPBWR1SLC6A9SCDCYP11B1 | |
| SCHEMBL6508250 | 0.82 | RHEB (0.47) | MAPK10AMY1AF7 | |
| SCHEMBL11020313 | 0.82 | CA2 (0.54) | ATRMAPK10AMY1A | |
| SCHEMBL10763275 | 0.81 | MAPK10 (0.42) | MAPK10SCD | |
| SCHEMBL10764183 | 0.80 | MAPK10 (0.41) | MAPK10AMY1AF7 | |
| SCHEMBL10765137 | 0.80 | ATR (0.57) | ATRNPBWR1SCD | |
| SCHEMBL11016112 | 0.80 | SCN9A (0.42) | MAPK10SMN1; SMN2 | |
| SCHEMBL11018857 | 0.80 | MAPT (0.44) | ATRMAPK10AMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0209707-A2 | 2-Aryl imidazoles, pharmaceutical compositions containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1987-01-28 | — | — | EP | disclosed |