Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.32 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.31 |
| ▸ | PDE5A | O76074 | 2/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.31 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10764068 | 0.84 | PDE3B (0.33) | PDE3APDE3BPBRM1BRD4CREBBP | |
| SCHEMBL10762076 | 0.84 | PBRM1 (0.36) | PDE3APDE3BPBRM1BRD4CREBBP | |
| SCHEMBL10760108 | 0.82 | MAPT (0.35) | PTGS2PDE3APDE3BPBRM1BRD4 | |
| SCHEMBL10766286 | 0.81 | PDE3B (0.38) | PDE3APDE3BPBRM1TNNC1 | |
| SCHEMBL10762902 | 0.80 | PDE3A (0.43) | PTGS2PDE3APDE3BPBRM1BRD4 | |
| SCHEMBL10765095 | 0.80 | PDE3B (0.33) | PDE3APDE3BPBRM1BRD4CREBBP | |
| SCHEMBL10764370 | 0.80 | PDE3B (0.34) | PDE3APDE3BPBRM1BRD4CREBBP | |
| SCHEMBL10763298 | 0.80 | PDE3A (0.39) | PTGS2PDE3APDE3BPBRM1BRD4 | |
| SCHEMBL10765719 | 0.79 | PDE3A (0.38) | PTGS2PDE3APDE3BPDE4BGPR119 | |
| SCHEMBL10763897 | 0.79 | PDE3A (0.40) | PTGS2PDE3APDE3BPDE4BGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210530-A1 | 6-Arylalkenyl pyridazinones | MERCK PATENT GmbH (DE) | 1987-02-04 | — | — | EP | disclosed |