Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Oxytetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.69 |
| ▸ | MEN1 | O00255 | 9/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.69 |
| ▸ | USP2 | O75604 | 7/20 | 0.69 |
| ▸ | HPGD | P15428 | 6/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | RECQL | P46063 | 5/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | THRB | P10828 | 4/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxytetracycline SCHEMBL28914839 | 0.99 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL2353677 | 0.99 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL20740451 | 0.99 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL20740448 | 0.99 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL2898 | 0.99 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL21409869 | 0.98 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL22769463 | 0.98 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL11331676 | 0.98 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL3954956 | 0.98 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL459700 | 0.98 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052404-B1 | NON-YELLOWING TOPICAL PHARMACEUTICAL COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 1987-05-27 | — | — | EP | disclosed |
| EP-0052404-A2 | Non-yellowing topical pharmaceutical composition | THE PROCTER & GAMBLE COMPANY (US) | 1982-05-26 | — | — | EP | disclosed |
| US-4150114-A | ENHANCED PENETRATION | THE PROCTER & GAMBLE COMPANY (US) | 1979-04-17 | — | — | US | disclosed |
| US-4148893-A | SUGAR ESTER AND DIALKYL SULFOXIDE ENHANCE PENETRATION THROUGH SKIN | THE PROCTER & GAMBLE COMPANY (US) | 1979-04-10 | — | — | US | disclosed |
| US-4148924-A | Dermatological compositions | THE PROCTER & GAMBLE COMPANY (US) | 1979-04-10 | — | — | US | disclosed |
| US-4148874-A | ENHANCE PENETRATION OF PHARMOCOLOGICALLY ACTIVE AGENTS THROUGH THE SKIN | THE PROCTER & GAMBLE COMPANY (US) | 1979-04-10 | — | — | US | disclosed |
| US-4148887-A | SUGAR ESTER WITH A METHYL SULFOXIDE | THE PROCTER & GAMBLE COMPANY (US) | 1979-04-10 | — | — | US | disclosed |
| US-4148917-A | PENETRATION | THE PROCTER & GAMBLE COMPANY (US) | 1979-04-10 | — | — | US | disclosed |
| US-4130667-A | A SUCROSE ESTER AND A PHOSPHINE OXIDE | THE PROCTER & GAMBLE COMPANY (US) | 1978-12-19 | — | — | US | disclosed |
| US-4130643-A | STEROID, SUCROSE ESTER, SULFOXIDE | THE PROCTER & GAMBLE COMPANY (US) | 1978-12-19 | — | — | US | disclosed |
| US-4046886-A | SUGAR ESTER, PHOSPHINE OXIDE | THE PROCTER & GAMBLE COMPANY (US) | 1977-09-06 | — | — | US | disclosed |
| US-3952099-A | MICROBIOCIDE, SUGAR ESTER, SULFOXIDE | THE PROCTER & GAMBLE COMPANY (US) | 1976-04-20 | — | — | US | disclosed |