Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Oxytetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.70 |
| ▸ | MEN1 | O00255 | 9/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.70 |
| ▸ | USP2 | O75604 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 6/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.70 |
| ▸ | RECQL | P46063 | 5/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | THRB | P10828 | 4/20 | 0.69 |
| ▸ | POLB | P06746 | 3/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.69 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxytetracycline SCHEMBL20740448 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL2898 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL2353677 | 1.00 | TDP1 (0.70) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL22769463 | 0.99 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL11331676 | 0.99 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL21409869 | 0.99 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL3954956 | 0.99 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL10765981 | 0.99 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL459700 | 0.99 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 | |
| Oxytetracycline SCHEMBL2806490 | 0.99 | TDP1 (0.69) | TDP1MEN1KMT2AKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240197767-A1 | COMBINATION OF ZIDOVUDINE WITH A TETRACYCLINE ANTIBIOTIC | HELPERBY THERAPEUTICS LIMITED (GB) | 2024-06-20 | — | — | US | disclosed |
| US-11498743-B2 | Cardboard container for active packaging of fresh fruit and vegetables and production method of same | UNIVERSIDAD POLITECNICA DE CARTAGENA (ES) | 2022-11-15 | — | — | US | disclosed |
| EP-4045055-A1 | COMBINATION OF ZIDOVUDINE WITH A TETRACYCLINE ANTIBIOTIC | Helperby Therapeutics Limited (GB) | 2022-08-24 | — | — | EP | disclosed |
| CN-114765956-A | Combinations of zidovudine and tetracycline antibiotics | 赫尔普百治疗有限公司 | 2022-07-19 | — | — | CN | disclosed |
| WO-2021074598-A1 | COMBINATION OF ZIDOVUDINE WITH A TETRACYCLINE ANTIBIOTIC | HELPERBY THERAPEUTICS LIMITED (GB) | 2021-04-22 | — | — | WO | disclosed |
| EP-3444203-B1 | CARDBOARD CONTAINER FOR ACTIVE PACKAGING OF FRESH FRUIT AND VEGETABLES AND PRODUCTION METHOD OF SAME | UNIV CARTAGENA POLITECNICA (ES) | 2020-08-05 | — | — | EP | disclosed |
| US-20190092550-A1 | CARDBOARD CONTAINER FOR ACTIVE PACKAGING OF FRESH FRUIT AND VEGETABLES AND PRODUCTION METHOD OF SAME | UNIV CARTAGENA POLITECNICA (ES) | 2019-03-28 | — | — | US | disclosed |
| EP-3444203-A1 | CARDBOARD CONTAINER FOR ACTIVE PACKAGING OF FRESH FRUIT AND VEGETABLES AND PRODUCTION METHOD OF SAME | Universidad Politecnica de Cartagena (ES) | 2019-02-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240197767-A1 | COMBINATION OF ZIDOVUDINE WITH A TETRACYCLINE ANTIBIOTIC | TYMS, TYMP, DHFR | TDP1 2082/4885MEN1 4310/4885KMT2A 879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.