Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Oxytetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.69 |
| ▸ | MEN1 | O00255 | 8/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.69 |
| ▸ | RECQL | P46063 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.69 |
| ▸ | HPGD | P15428 | 6/20 | 0.69 |
| ▸ | USP2 | O75604 | 6/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.69 |
| ▸ | THRB | P10828 | 5/20 | 0.68 |
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxytetracycline SCHEMBL28245415 | 0.99 | TDP1 (0.70) | TDP1KDM4EMEN1KMT2AL3MBTL1 | |
| Oxytetracycline SCHEMBL29365107 | 0.99 | TDP1 (0.70) | TDP1KDM4EMEN1KMT2AL3MBTL1 | |
| Oxytetracycline SCHEMBL113193 | 0.99 | TDP1 (0.70) | TDP1KDM4EMEN1KMT2AL3MBTL1 | |
| Oxytetracycline SCHEMBL124996 | 0.99 | TDP1 (0.70) | TDP1KDM4EMEN1KMT2AL3MBTL1 | |
| Oxytetracycline SCHEMBL2353677 | 0.99 | TDP1 (0.70) | TDP1KDM4EMEN1KMT2AL3MBTL1 | |
| Oxytetracycline SCHEMBL2898 | 0.99 | TDP1 (0.70) | TDP1KDM4EMEN1KMT2AL3MBTL1 | |
| Oxytetracycline SCHEMBL5489972 | 0.99 | TDP1 (0.70) | TDP1KDM4EMEN1KMT2AL3MBTL1 | |
| Oxytetracycline SCHEMBL20740451 | 0.99 | TDP1 (0.70) | TDP1KDM4EMEN1KMT2AL3MBTL1 | |
| Oxytetracycline SCHEMBL20740448 | 0.99 | TDP1 (0.70) | TDP1KDM4EMEN1KMT2AL3MBTL1 | |
| Oxytetracycline SCHEMBL22769463 | 0.98 | TDP1 (0.69) | TDP1KDM4EMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 271 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111393319-B | Preparation method of oxytetracycline chloride | 山东国邦药业有限公司 | 2023-03-28 | — | — | CN | claimed |
| CN-114315627-B | Method for synthesizing doxycycline dehydrate by catalyzing with normal-temperature ionic liquid and zeolite | 扬州联博药业有限公司 | 2023-03-21 | — | — | CN | claimed |
| CN-113149855-B | Method for synthesizing 11 alpha-chloromethyloxytetracycline p-toluenesulfonate | 山东国邦药业有限公司 | 2022-08-09 | — | — | CN | claimed |
| CN-114315627-A | Method for synthesizing doxycycline dehydrate by catalyzing with normal-temperature ionic liquid and zeolite | 扬州联博药业有限公司 | 2022-04-12 | — | — | CN | claimed |
| CN-113149855-A | Method for synthesizing 11 alpha-chloromethyloxytetracycline p-toluenesulfonate | 山东国邦药业有限公司 | 2021-07-23 | — | — | CN | claimed |
| CN-111393319-A | Preparation method of oxytetracycline chloride | 山东国邦药业有限公司 | 2020-07-10 | — | — | CN | claimed |
| EP-3160943-B1 | MOLECULES HAVING CERTAIN PESTICIDAL UTILITIES, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES RELATED THERETO | DOW AGROSCIENCES LLC (US) | 2019-09-18 | — | — | EP | claimed |
| EP-2805710-B1 | Method for fabricating a drug-carrying contact lens | UNIV NATIONAL CHIAO TUNG (TW) | 2018-04-18 | — | — | EP | claimed |
| EP-2543358-B1 | Drug carrying contact lens | UNIV NAT CHIAO TUNG (TW) | 2015-04-29 | — | — | EP | claimed |
| EP-2805710-A1 | Method for fabricating a drug-carrying contact lens | National Chiao Tung University (TW) | 2014-11-26 | — | — | EP | claimed |
| US-7160558-B2 | Coating and binding agent for pharmaceutical formulations with improved storage stability | ROEHM GMBH & CO. KG (DE) | 2007-01-09 | — | — | US | claimed |
| US-20030064036-A1 | Coating and binding agent for pharmaceutical formulations with improved storage stability | ROEHM GMBH (DE) | 2003-04-03 | — | — | US | claimed |
| US-6365178-B1 | DISSOLVING HYDROPHILIC SALT OF DRUG IN AQUEOUS DISPERSION OF HYDROPHOBIC PRESSURE SENSITIVE ADHESIVE, CASTING MIXTURE AND EVAPORATING WATER TO OBTAIN FILM, LAMINATING RELEASE LINER TO ONE SURFACE AND DRUG IMPERMEABLE BACKING LAYER TO OTHER | WATSON PHARMACEUTICALS, INC. | 2002-04-02 | — | — | US | claimed |
| EP-1117389-A1 | METHOD OF MAKING PRESSURE SENSITIVE ADHESIVE MATRIX PATCHES CONTAINING HYDROPHILIC SALTS OF DRUGS | TheraTech, Inc. (US) | 2001-07-25 | — | — | EP | claimed |
| WO-2000024386-A1 | METHOD OF MAKING PRESSURE SENSITIVE ADHESIVE MATRIX PATCHES CONTAINING HYDROPHILIC SALTS OF DRUGS | THERATECH, INC. (US) | 2000-05-04 | — | — | WO | claimed |
| US-5985317-A | POLYISOBUTYLENE; BACKING IMPERMEABLE TO DICLOFENAC SODIUM | THERATECH, INC. (US) | 1999-11-16 | — | — | US | claimed |
| EP-0952799-A1 | PRESSURE SENSITIVE ADHESIVE MATRIX PATCHES FOR TRANSDERMAL DELIVERY OF SALTS OF PHARMACEUTICAL AGENTS | THERATECH, INC. (US) | 1999-11-03 | — | — | EP | claimed |
| WO-1998009591-A1 | PRESSURE SENSITIVE ADHESIVE MATRIX PATCHES FOR TRANSDERMAL DELIVERY OF SALTS OF PHARMACEUTICAL AGENTS | THERATECH, INC. (US) | 1998-03-12 | — | — | WO | claimed |
| EP-0412770-B1 | Polysiloxane-grafted copolymer topical binder composition with novel hydrophilic monomers and method of coating therewith | MINNESOTA MINING & MFG (US) | 1995-10-04 | — | — | EP | claimed |
| US-5035891-A | Sustained release of animal growth promoters for livestock, anticancer agents for humans | SYNTEX (U.S.A.) INC. (US) | 1991-07-30 | — | — | US | claimed |