Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | TLR4 | O00206 | 2/20 | 0.32 |
| ▸ | TLR2 | O60603 | 2/20 | 0.32 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 4/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1076898 | 1.00 | P2RX7 (0.32) | P2RX7TLR4TLR2LRRK2KDM5A | |
| SCHEMBL1077624 | 0.89 | TLR4 (0.33) | P2RX7TLR4TLR2LRRK2ACHE | |
| SCHEMBL1077627 | 0.89 | TLR4 (0.33) | P2RX7TLR4TLR2LRRK2ACHE | |
| SCHEMBL6525258 | 0.88 | TLR4 (0.34) | P2RX7TLR4TLR2LRRK2KDM5A | |
| SCHEMBL6518264 | 0.82 | CYP3A4 (0.33) | P2RX7KDM5AKDM4CKDM5B | |
| SCHEMBL6518270 | 0.82 | CYP3A4 (0.33) | P2RX7KDM5AKDM4CKDM5B | |
| SCHEMBL1035414 | 0.80 | POLB (0.31) | — | |
| SCHEMBL1035415 | 0.80 | POLB (0.31) | — | |
| SCHEMBL6522748 | 0.78 | TLR4 (0.41) | TLR4TLR2ACHE | |
| SCHEMBL1036413 | 0.78 | FAAH (0.35) | TLR4TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276738-A1 | ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS | Pfizer Inc. (US) | 2011-01-26 | — | — | EP | claimed |
| WO-2009127943-A1 | ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS | PFIZER INC. (US) | 2009-10-22 | — | — | WO | claimed |