Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10666860 | 0.80 | NPC1 (0.57) | KMT2ANPC1RAB9AKDM4EPKM | |
| SCHEMBL6442937 | 0.78 | CYP3A4 (0.40) | NPC1RAB9AKDM4EPKMSMN1; SMN2 | |
| SCHEMBL6483036 | 0.77 | NPC1 (0.64) | KMT2ANPC1RAB9AKDM4EPKM | |
| SCHEMBL6475549 | 0.74 | NOS2 (0.38) | RPS6KA3ESR1 | |
| SCHEMBL10617498 | 0.69 | ESR1 (0.34) | ESR1 | |
| SCHEMBL10617565 | 0.67 | ADORA3 (0.44) | KMT2ANPC1RAB9AKDM4EPDE10A | |
| SCHEMBL6880563 | 0.63 | CBFB (0.51) | ALDH1A1ESR1MAPK10 | |
| SCHEMBL423547 | 0.63 | NPC1 (0.58) | KMT2ANPC1RAB9AKDM4ETSHR | |
| SCHEMBL22499408 | 0.62 | NPC1 (0.51) | KMT2ANPC1RAB9AKDM4ETSHR | |
| SCHEMBL6475793 | 0.61 | ATP4A (0.57) | KMT2ANPC1RAB9AKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0242341-A1 | Benzimidazoles, process for their preparation and preparations containing same | Aktiebolaget Hässle (SE) | 1987-10-21 | — | — | EP | disclosed |
| WO-1987005021-A1 | BENZIMIDAZOLES AND THEIR PHARMACEUTICAL USE | Aktiebolaget Hässle (SE) | 1987-08-27 | — | — | WO | disclosed |