Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26694859 | 0.77 | KDM4E (0.38) | KDM4EPOLBIDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25145416 | 0.77 | KDM4E (0.40) | KDM4EPOLBIDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8344113 | 0.75 | KDM4E (0.54) | KDM4EPOLBIDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10412021 | 0.75 | SMN1; SMN2 (0.54) | POLBALDH1A1MAPK1SMN1; SMN2HPGD | |
| SCHEMBL1279214 | 0.75 | KDM4E (0.54) | KDM4EPOLBIDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21516636 | 0.75 | ALDH1A1 (0.43) | KDM4EPOLBALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL8883011 | 0.73 | KDM4E (0.52) | KDM4EPOLBIDO1ALDH1A1MAPK1 | |
| SCHEMBL1744864 | 0.73 | KDM4E (0.47) | KDM4EPOLBIDO1ALDH1A1SMN1; SMN2 | |
| SCHEMBL3886713 | 0.71 | POLB (0.53) | KDM4EPOLBIDO1ALDH1A1MAPK1 | |
| SCHEMBL29513014 | 0.71 | POLB (0.53) | KDM4EPOLBIDO1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4668675-A | ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-05-26 | — | — | US | disclosed |
| US-4556667-A | (2-((AMINOPYRIDINYL)AMINO)PHENYL)ARYLMETHANONE INTERMEDIATES | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-12-03 | — | — | US | disclosed |
| US-4495183-A | ANTIULCER AGENTS- GASTROLINTESTINAL DISORDERS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-01-22 | — | — | US | disclosed |
| US-4447361-A | ANTIDEPRESSANT | A. H. ROBINS COMPANY, INC. (US) | 1984-05-08 | — | — | US | disclosed |