Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | BLM | P54132 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methoxymethane SCHEMBL10777820 | 0.81 | BLM (0.45) | KDM4EHSD17B10MAPTHPGDALDH1A1 | |
| Methoxymethane SCHEMBL10782344 | 0.81 | BLM (0.45) | KDM4EHSD17B10MAPTHPGDALDH1A1 | |
| SCHEMBL10779084 | 0.81 | ALDH1A1 (0.47) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL10779111 | 0.81 | ALDH1A1 (0.47) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL10778646 | 0.78 | SMN1; SMN2 (0.47) | KDM4EALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL12608355 | 0.77 | HSD17B10 (0.48) | KDM4EHSD17B10MAPTHPGDALDH1A1 | |
| SCHEMBL11533258 | 0.77 | HSD17B10 (0.65) | KDM4EHSD17B10MAPTHPGDALDH1A1 | |
| SCHEMBL11883650 | 0.76 | HSD17B10 (0.44) | KDM4EHSD17B10MAPTHPGDALDH1A1 | |
| SCHEMBL12608299 | 0.74 | MAPT (0.48) | KDM4EHSD17B10MAPTHPGDALDH1A1 | |
| SCHEMBL11534896 | 0.73 | HSD17B10 (0.60) | KDM4EHSD17B10MAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4695588-A | DECARBOXYLASE INHIBITORS | MERCK & CO., INC. (US) | 1987-09-22 | — | — | US | disclosed |
| US-4325961-A | FLUOROMETHYLHISTIDINE, ESTERS, AND SALTS | MERCK & CO., INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4288601-A | A-FLUOROMETHYL AMINO ACIDS FROM THE A-HYDROXYMETHYL COMPOUND USING SULFUR TETRAFLUORIDE AND BORON TRIFLUORIDE IN HYDROFLUORIC ACID | MERCK & CO., INC. (US) | 1981-09-08 | — | — | US | disclosed |
| US-4215221-A | A-FLUOROMETHYL AMINO ACIDS FROM THE A-HYDROXYMETHYL COMPOUNDS USING SULFUR TETRAFLUORIDE IN HYDROFLUORIC ACID AND ALUMINUM CHLORIDE | MERCK & CO., INC. (US) | 1980-07-29 | — | — | US | disclosed |