SCHEMBL10779111

SCHEMBL10779111

COc1ccc(CC(CO)(NC(C)=O)C(=O)O)cc1OC

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
LDHA P00338 1/20 0.47
POLB P06746 1/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.42
CA2 P00918 3/20 0.42
CA1 P00915 2/20 0.42
CA9 Q16790 2/20 0.42
CA12 O43570 1/20 0.42
MTNR1A P48039 1/20 0.41
MTNR1B P49286 1/20 0.41
KDM4E B2RXH2 1/20 0.41
EPHX2 P34913 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10779084 1.00 ALDH1A1 (0.47) ALDH1A1LDHAPOLBMEN1KMT2A
SCHEMBL10778646 0.82 SMN1; SMN2 (0.47) ALDH1A1LDHAPOLBSMN1; SMN2MTNR1A
SCHEMBL11400542 0.81 ALDH1A1 (0.49) ALDH1A1LDHAPOLBMEN1KMT2A
SCHEMBL11400920 0.81 ALDH1A1 (0.49) ALDH1A1LDHAPOLBMEN1KMT2A
SCHEMBL10777945 0.81 KDM4E (0.54) ALDH1A1POLBMEN1KMT2ASMN1; SMN2
Methoxymethane SCHEMBL10777820 0.80 BLM (0.45) ALDH1A1POLBMEN1KMT2ASMN1; SMN2
Methoxymethane SCHEMBL10782344 0.80 BLM (0.45) ALDH1A1POLBMEN1KMT2ASMN1; SMN2
SCHEMBL12608328 0.78 ALDH1A1 (0.43) ALDH1A1LDHAPOLBSMN1; SMN2MTNR1A
SCHEMBL11558748 0.76 ALDH1A1 (0.47) ALDH1A1LDHAPOLBMEN1KMT2A
SCHEMBL12608309 0.75 ALDH1A1 (0.45) ALDH1A1LDHAPOLBMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4695588-A DECARBOXYLASE INHIBITORS MERCK & CO., INC. (US) 1987-09-22 US disclosed
US-4325961-A FLUOROMETHYLHISTIDINE, ESTERS, AND SALTS MERCK & CO., INC. (US) 1982-04-20 US disclosed
US-4288601-A A-FLUOROMETHYL AMINO ACIDS FROM THE A-HYDROXYMETHYL COMPOUND USING SULFUR TETRAFLUORIDE AND BORON TRIFLUORIDE IN HYDROFLUORIC ACID MERCK & CO., INC. (US) 1981-09-08 US disclosed
US-4215221-A A-FLUOROMETHYL AMINO ACIDS FROM THE A-HYDROXYMETHYL COMPOUNDS USING SULFUR TETRAFLUORIDE IN HYDROFLUORIC ACID AND ALUMINUM CHLORIDE MERCK & CO., INC. (US) 1980-07-29 US disclosed