Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.52 |
| ▸ | ACE | P12821 | 7/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13928545 | 0.84 | PREP (0.56) | PREPACECAPN1 | |
| SCHEMBL13950861 | 0.84 | PREP (0.56) | PREPACECAPN1 | |
| SCHEMBL10777993 | 0.82 | CTRB1 (0.47) | PREPCTRB1 | |
| SCHEMBL7334484 | 0.77 | PREP (0.72) | PREPACE | |
| SCHEMBL22209468 | 0.77 | PREP (0.72) | PREPACE | |
| SCHEMBL7871516 | 0.77 | PREP (0.72) | PREPACE | |
| SCHEMBL5711352 | 0.76 | PREP (0.57) | PREPACECAPN1 | |
| SCHEMBL9438697 | 0.76 | PREP (0.67) | PREPACE | |
| SCHEMBL9438701 | 0.76 | PREP (0.67) | PREPACE | |
| SCHEMBL9438980 | 0.76 | PREP (0.67) | PREPACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052991-B1 | CARBOXYALKYL AMINO ACID DERIVATIVES OF VARIOUS SUBSTITUTED PROLINES | E.R. Squibb & Sons, Inc. (US) | 1987-02-04 | — | — | EP | disclosed |
| US-4462943-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-07-31 | — | — | US | disclosed |
| EP-0052991-A1 | Carboxyalkyl amino acid derivatives of various substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-06-02 | — | — | EP | disclosed |