Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.50 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.50 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.42 |
| ▸ | HTR3B | O95264 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.42 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.42 |
| ▸ | FADS1 | O60427 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368850 | 0.83 | SMN1; SMN2 (0.50) | KMT2AMEN1ALDH1A1GUCY1B2MAPT | |
| SCHEMBL8368911 | 0.83 | MAPT (0.50) | KMT2AMEN1ALDH1A1GUCY1B2MAPT | |
| SCHEMBL8368653 | 0.82 | MAPT (0.70) | KMT2AMEN1ALDH1A1GUCY1B2MAPT | |
| SCHEMBL29633296 | 0.75 | MAPT (0.69) | KMT2AMEN1ALDH1A1GUCY1B2MAPT | |
| SCHEMBL16296863 | 0.75 | MAPT (0.69) | KMT2AMEN1ALDH1A1GUCY1B2MAPT | |
| SCHEMBL8367302 | 0.74 | CDK4 (0.56) | KMT2AMEN1ALDH1A1GUCY1B2MAPT | |
| SCHEMBL8371672 | 0.74 | CDK4 (0.58) | KMT2AMEN1ALDH1A1GUCY1B2MAPT | |
| SCHEMBL4058567 | 0.71 | KMT2A (0.41) | KMT2AMEN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8368885 | 0.70 | MEN1 (0.48) | KMT2AMEN1ALDH1A1GUCY1B2MAPT | |
| SCHEMBL8369508 | 0.70 | CDK4 (0.60) | KMT2AMEN1ALDH1A1GUCY1B2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107365-B1 | 6-ANILINO-5,8-QUINOXALINEDIONES | ELI LILLY AND COMPANY (US) | 1987-07-22 | — | — | EP | claimed |
| EP-0107365-A2 | 6-Anilino-5,8-quinoxalinediones | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | claimed |
| EP-0107365-B1 | 6-ANILINO-5,8-QUINOXALINEDIONES | ELI LILLY AND COMPANY (US) | 1987-07-22 | — | — | EP | disclosed |
| US-4486432-A | ANTIASTHMA | ELI LILLY AND COMPANY (US) | 1984-12-04 | — | — | US | disclosed |
| EP-0107365-A2 | 6-Anilino-5,8-quinoxalinediones | ELI LILLY AND COMPANY (US) | 1984-05-02 | — | — | EP | disclosed |