SCHEMBL8367302

SCHEMBL8367302

O=C1C=C(Nc2ccc(F)cc2)C(=O)c2nccnc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 9/20 0.56
CASP3 P42574 3/20 0.55
SENP8 Q96LD8 3/20 0.55
SENP7 Q9BQF6 3/20 0.55
SENP6 Q9GZR1 3/20 0.55
MAPT P10636 5/20 0.51
SMN1; SMN2 Q16637 4/20 0.51
MEN1 O00255 3/20 0.51
KMT2A Q03164 3/20 0.51
TDP1 Q9NUW8 3/20 0.51
ALDH1A1 P00352 3/20 0.51
GUCY1B2 O75343 1/20 0.51
GUCY1A2 P33402 1/20 0.51
GUCY1A1 Q02108 1/20 0.51
GUCY1B1 Q02153 1/20 0.51
NQO1 P15559 2/20 0.43
BLM P54132 4/20 0.42
THRB P10828 1/20 0.42
CCND1 P24385 1/20 0.42
KMT5A Q9NQR1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8371672 0.84 CDK4 (0.58) CDK4CASP3SENP8SENP7SENP6
SCHEMBL8368653 0.84 MAPT (0.70) CDK4CASP3SENP8SENP7SENP6
SCHEMBL8656092 0.82 MAPT (0.77) CDK4CASP3SENP8SENP7SENP6
SCHEMBL8368911 0.82 MAPT (0.50) CDK4CASP3SENP8SENP7SENP6
SCHEMBL8369508 0.81 CDK4 (0.60) CDK4MAPTSMN1; SMN2MEN1KMT2A
SCHEMBL8368885 0.81 MEN1 (0.48) CDK4MAPTSMN1; SMN2MEN1KMT2A
SCHEMBL8548036 0.79 CDK4 (0.64) CDK4CASP3SENP8SENP7SENP6
SCHEMBL8369531 0.77 CASP3 (0.51) CDK4CASP3SENP8SENP7SENP6
SCHEMBL8370509 0.77 CASP3 (0.48) CDK4CASP3SENP8SENP7SENP6
SCHEMBL8368877 0.76 KMT2A (0.46) CASP3SENP8SENP7SENP6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0866692-A1 USE OF BICYCLIC MONO- OR DIKETONE DERIVATIVES, RESULTING COMPOUNDS, AND USE THEREOF AS A DRUG FOR TREATING INFLAMMATION, MIGRAINE AND SHOCK LABORATOIRE INNOTHERA Société Anonyme (FR) 1998-09-30 EP claimed
WO-1997021432-A1 USE OF BICYCLIC MONO- OR DIKETONE DERIVATIVES, RESULTING COMPOUNDS, AND USE THEREOF AS A DRUG FOR TREATING INFLAMMATION, MIGRAINE AND SHOCK LABORATOIRE INNOTHERA, S.A. (FR) 1997-06-19 WO claimed
WO-1999052365-A1 ANTICANCER AGENTS ELI LILLY AND COMPANY (US) 1999-10-21 WO disclosed
EP-0866692-A1 USE OF BICYCLIC MONO- OR DIKETONE DERIVATIVES, RESULTING COMPOUNDS, AND USE THEREOF AS A DRUG FOR TREATING INFLAMMATION, MIGRAINE AND SHOCK LABORATOIRE INNOTHERA Société Anonyme (FR) 1998-09-30 EP disclosed
WO-1997021432-A1 USE OF BICYCLIC MONO- OR DIKETONE DERIVATIVES, RESULTING COMPOUNDS, AND USE THEREOF AS A DRUG FOR TREATING INFLAMMATION, MIGRAINE AND SHOCK LABORATOIRE INNOTHERA, S.A. (FR) 1997-06-19 WO disclosed