Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10779405 | 1.00 | CTSL (0.51) | CTSLNPSR1CYP19A1MAOBMAPT | |
| SCHEMBL10916746 | 0.85 | ALDH1A1 (0.51) | CTSLNPSR1CYP19A1MAPTALDH1A1 | |
| SCHEMBL10780584 | 0.85 | ALDH1A1 (0.51) | CTSLNPSR1CYP19A1MAPTALDH1A1 | |
| SCHEMBL13114090 | 0.76 | NPSR1 (0.58) | CTSLNPSR1CYP19A1MAOBMAPT | |
| SCHEMBL20205932 | 0.76 | NPSR1 (0.62) | CTSLNPSR1CYP19A1MAOBMAPT | |
| SCHEMBL7878503 | 0.73 | CTSL (0.62) | CTSLNPSR1CYP19A1MAOBMAPT | |
| SCHEMBL29991312 | 0.73 | CTSL (0.62) | CTSLNPSR1CYP19A1MAOBMAPT | |
| SCHEMBL7878501 | 0.73 | CTSL (0.62) | CTSLNPSR1CYP19A1MAOBMAPT | |
| SCHEMBL21836221 | 0.69 | MEN1 (0.38) | CTSLNPSR1CYP19A1LMNAALDH1A1 | |
| SCHEMBL21836220 | 0.69 | MEN1 (0.38) | CTSLNPSR1CYP19A1LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0145895-B1 | INTERMEDIATES USEFUL IN THE PREPARATION OF CERTAIN CHIRAL HYDANTOINS, INCLUDING SORBINIL | PFIZER INC. (US) | 1987-03-04 | — | — | EP | disclosed |
| EP-0037672-B1 | PROCESS FOR THE PREPARATION OF CHIRAL HYDANTOINS, AND A NOVEL HYDANTOIN PRODUCED BY SAID PROCESS AND A PHARMACEUTICAL COMPOSITION CONTAINING IT | PFIZER INC. (US) | 1986-05-14 | — | — | EP | disclosed |
| EP-0145895-A1 | Intermediates useful in the preparation of certain chiral hydantoins, including sorbinil | PFIZER INC. (US) | 1985-06-26 | — | — | EP | disclosed |
| US-4419521-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1983-12-06 | — | — | US | disclosed |
| US-4348526-A | COMPLICATIONS OF DIABETES | PFIZER INC. (US) | 1982-09-07 | — | — | US | disclosed |
| EP-0037672-A2 | Process for the preparation of chiral hydantoins, and a novel hydantoin produced by said process and a pharmaceutical composition containing it | PFIZER INC. (US) | 1981-10-14 | — | — | EP | disclosed |
| US-4286098-A | HYPOGLYCEMIC AGENTS, TREATMENT OF DIABETES COMPLICATIONS | PFIZER INC. (US) | 1981-08-25 | — | — | US | disclosed |