Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 4/20 | 0.42 |
| ▸ | PEPD | P12955 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10779336 | 0.94 | ACE (0.42) | ACELMNARENPEPDHSD17B10 | |
| SCHEMBL10779744 | 0.91 | ACE (0.52) | ACELMNARENPEPDHSD17B10 | |
| SCHEMBL30406562 | 0.83 | KLK5 (0.46) | ACEPEPDHSD17B10XPNPEP1 | |
| SCHEMBL17955686 | 0.81 | HSD17B10 (0.44) | ACELMNARENPEPDHSD17B10 | |
| SCHEMBL7433056 | 0.81 | ACE (0.45) | ACELMNAPEPDSMN1; SMN2 | |
| SCHEMBL10771306 | 0.81 | ACE (0.45) | ACELMNAPEPDSMN1; SMN2 | |
| SCHEMBL7433053 | 0.81 | ACE (0.45) | ACELMNAPEPDSMN1; SMN2 | |
| SCHEMBL10768333 | 0.81 | ACE (0.45) | ACELMNAPEPDSMN1; SMN2 | |
| SCHEMBL10771310 | 0.81 | ACE (0.45) | ACELMNAPEPDSMN1; SMN2 | |
| SCHEMBL10971210 | 0.80 | ACE (0.51) | ACELMNAACE2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0084941-B1 | AMIDE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-03-11 | — | — | EP | disclosed |
| US-4528282-A | Amide derivatives | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1985-07-09 | — | — | US | disclosed |
| EP-0084941-A1 | Amide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-08-03 | — | — | EP | disclosed |