Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 10/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.42 |
| ▸ | REN | P00797 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PEPD | P12955 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10779423 | 0.91 | ACE (0.43) | ACELMNASMN1; SMN2RENKDM4E | |
| SCHEMBL10779336 | 0.90 | ACE (0.42) | ACELMNASMN1; SMN2RENKDM4E | |
| SCHEMBL11562020 | 0.87 | FKBP1A (0.46) | ACELMNAFKBP1ARENKDM4E | |
| SCHEMBL10520986 | 0.84 | ACE (0.50) | ACELMNASMN1; SMN2FKBP1APEPD | |
| SCHEMBL10520981 | 0.84 | ACE (0.50) | ACELMNASMN1; SMN2FKBP1APEPD | |
| SCHEMBL905844 | 0.83 | ACE (0.80) | ACELMNASMN1; SMN2ALOX15 | |
| SCHEMBL10935346 | 0.82 | CYP1A2 (0.50) | ACELMNASMN1; SMN2FKBP1AMAPT | |
| SCHEMBL10935341 | 0.82 | CYP1A2 (0.50) | ACELMNASMN1; SMN2FKBP1AMAPT | |
| SCHEMBL10610279 | 0.82 | ACE (0.60) | ACELMNASMN1; SMN2ALOX15ACE2 | |
| SCHEMBL21166676 | 0.81 | CTSL (0.51) | ACELMNASMN1; SMN2FKBP1APEPD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0084941-B1 | AMIDE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-03-11 | — | — | EP | disclosed |
| US-4528282-A | Amide derivatives | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1985-07-09 | — | — | US | disclosed |
| EP-0084941-A1 | Amide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-08-03 | — | — | EP | disclosed |