SCHEMBL1078320

SCHEMBL1078320

CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@]1(C)NC(=O)CCC1=O)C(=O)Nc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 2/20 0.42
FKBP4 Q02790 1/20 0.40
MMP3 P08254 8/20 0.39
MMP1 P03956 3/20 0.39
PSMB9 P28065 3/20 0.37
TRPV1 Q8NER1 1/20 0.37
MMP2 P08253 2/20 0.35
HPGD P15428 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
PRMT5 O14744 1/20 0.34
WDR77 Q9BQA1 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4898024 0.96 TACR1 (0.42) TACR1FKBP4MMP3MMP1PSMB9
SCHEMBL3314831 0.91 TACR1 (0.41) TACR1FKBP4TRPV1MMP2HPGD
SCHEMBL3513112 0.91 FKBP4 (0.44) TACR1FKBP4MMP3MMP1TRPV1
SCHEMBL366333 0.90 TACR1 (0.51) TACR1FKBP4PSMB9
SCHEMBL1088249 0.90 TACR1 (0.41) TACR1FKBP4MMP3MMP1TRPV1
SCHEMBL4824283 0.90 PDF (0.43) TACR1FKBP4
SCHEMBL3926322 0.89 TACR1 (0.41) TACR1FKBP4TRPV1MMP2HPGD
SCHEMBL6044127 0.89 TACR1 (0.49) TACR1FKBP4PSMB9KMT2A
SCHEMBL368075 0.87 TACR1 (0.39) TACR1FKBP4
SCHEMBL2029990 0.85 TACR1 (0.52) TACR1FKBP4PSMB9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2534483-B1 TEST ARRANGEMENT SIGL EVA (AT) 2016-09-14 EP disclosed
CN-101243182-B Subtilases NOVO NORDISK AS 2014-08-06 CN disclosed
US-20140127782-A1 Subtilases NOVOZYMES A/S (DK) 2014-05-08 US disclosed
US-8658410-B2 Subtilases NOVOZYMES A/S (DK) 2014-02-25 US disclosed
US-20130045524-A1 Subtilases NOVOZYMES A/S (DK) 2013-02-21 US disclosed
US-8318470-B2 Subtilases NOVOZYMES A/S (DK) 2012-11-27 US disclosed
US-8232087-B2 Subtilases NOVOZYMES A/S (DK) 2012-07-31 US disclosed
US-20120101019-A1 Subtilases NOVOZYMES A/S (DK) 2012-04-26 US disclosed
EP-1794296-B1 Subtilases NOVOZYMES AS (DK) 2012-04-18 EP disclosed
EP-1794295-B1 SUBTILASES NOVOZYMES AS (DK) 2011-11-16 EP disclosed
WO-2005013090-A2 SYSTEMS AND METHODS FOR BIOPOLYMER ENGINEERING DNA TWOPOINTO INC. (US) 2005-02-10 WO disclosed
WO-2005012877-A2 SYSTEMS AND METHODS FOR ANTIBODY ENGINEERING DNA TWOPOINTO INC. (US) 2005-02-10 WO disclosed
US-5972683-A THE SUBTILISIN YAB MUTANTS CAN BE USED IN VARIOUS ASPECTS SUCH AS THE QUALITY IMPROVEMENT OF MEAT AND THE PROTEIN PROCESSING FOR FOODSTUFF AND FEEDSTUFF. NATIONAL SCIENCE COUNCIL (TW) 1999-10-26 US disclosed
EP-0824592-A1 ALKALINE PROTEASE AND PROCESS FOR ITS PRODUCTION NOVO NORDISK BIOTECH, INC. (US) 1998-02-25 EP disclosed
US-5650326-A Promoter element and signal peptide of a gene encoding a Bacillus alkaline protease and vectors comprising same NOVO NORDISK BIOTECH, INC. (US) 1997-07-22 US disclosed
US-5622850-A CULTURE PRODUCT BY GENETIC ENGINEERING NOVO NORDISK BIOTECH, INC. (US) 1997-04-22 US disclosed
US-5622841-A TRANSFORMING HOST CELL WITH A VACTOR, VECTOR CONSISTS OF PROMOTER WHICH COMPRISES A TRANSCRIPTIONAL ACTIVATING REGION OF A SPECIFIC NUCLEIC ACID SEQUENCE, CULTURING, AND RECOVERING THE HETEROLOGOUS POLYPEPTIDE NOVO NORDISK BIOTECH, INC. (US) 1997-04-22 US disclosed
US-5621089-A Nucleic acid constructs for the production of a Bacillus alkaline protease NOVO NORDISK BIOTECH, INC. (US) 1997-04-15 US disclosed
US-5585253-A Extracellular serine protease and a Bacillus subtilis alkaline neutral an serine protease mutant strain THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-12-17 US disclosed
WO-1996034963-A1 ALKALINE PROTEASE AND PROCESS FOR ITS PRODUCTION NOVO NORDISK BIOTECH, INC. (US) 1996-11-07 WO disclosed