SCHEMBL366333

SCHEMBL366333

C[C@H](NC(=O)[C@]1(C)NC(=O)CCC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.51

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 7/20 0.51
FKBP4 Q02790 2/20 0.51
PSMB9 P28065 1/20 0.42
CMA1 P23946 2/20 0.41
MAPT P10636 1/20 0.41
ITGB1 P05556 3/20 0.41
ITGA4 P13612 3/20 0.41
USP30 Q70CQ3 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2029990 0.95 TACR1 (0.52) TACR1FKBP4PSMB9MAPTITGB1
SCHEMBL6044127 0.93 TACR1 (0.49) TACR1FKBP4PSMB9ITGB1ITGA4
SCHEMBL1078320 0.90 TACR1 (0.42) TACR1FKBP4PSMB9
SCHEMBL1882407 0.90 TACR1 (0.53) TACR1FKBP4PSMB9MAPTITGB1
SCHEMBL3513112 0.90 FKBP4 (0.44) TACR1FKBP4CMA1MAPTITGB1
SCHEMBL3314831 0.89 TACR1 (0.41) TACR1FKBP4MAPT
SCHEMBL1088249 0.88 TACR1 (0.41) TACR1FKBP4MAPTITGB1ITGA4
SCHEMBL4824283 0.87 PDF (0.43) TACR1FKBP4
SCHEMBL4898024 0.87 TACR1 (0.42) TACR1FKBP4PSMB9
SCHEMBL9011368 0.87 TACR1 (0.52) TACR1FKBP4PSMB9MAPTITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 548 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7108988-B2 Methods of identifying agents for inhibiting lentivirus replication THE J. DAVID GLADSTONE INSTITUTES (US) 2006-09-19 US claimed
US-20040009909-A1 Methods for inhibiting lentivirus replication NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2004-01-15 US claimed
US-5646028-A CLEANING THE CLOROX COMPANY (US) 1997-07-08 US claimed
US-5244791-A Methods of ester hydrolysis GENECOR INTERNATIONAL, INC. (US) 1993-09-14 US claimed
EP-4740954-A2 COMPOSITIONS AND METHODS FOR TREATMENT OF NETHERTON SYNDROME WITH LEKTI EXPRESSING RECOMBINANT MICROBES AZITRA, INC. (US) 2026-05-13 EP disclosed
EP-3638369-B1 COMPOSITIONS AND METHODS FOR TREATMENT OF NETHERTON SYNDROME WITH LEKTI EXPRESSING RECOMBINANT MICROBES AZITRA INC (US) 2026-04-29 EP disclosed
EP-4728032-A1 STABILIZED CLEANING COMPOSITIONS COMPRISING EDDS AND ENZYMES AND THEIR USE BASF SE (DE) 2026-04-22 EP disclosed
US-12606610-B2 Compositions and methods for treatment of Netherton Syndrome with LEKTI expressing recombinant microbes AZITRA INC (US) 2026-04-21 US disclosed
US-20260098231-A1 DETERGENT COMPOSITIONS, POLYMERS AND METHODS OF MANUFACTURING THE SAME BASF SE (DE) 2026-04-09 US disclosed
EP-4722322-A1 CLEANING COMPOSITIONS COMPRISING A PROTEASE BASF SE (DE) 2026-04-08 EP disclosed
EP-4722324-A1 CLEANING COMPOSITIONS COMPRISING A MANNANASE BASF SE (DE) 2026-04-08 EP disclosed
US-12576140-B2 Cyclophilin 40 for reduction of neurotoxic fibrils and treatment of neurodegenerative diseases UNIVERSITY OF SOUTH FLORIDA (US) 2026-03-17 US disclosed
WO-1989009819-A1 COMBINING MUTATIONS FOR STABILIZATION OF SUBTILISIN GENEX CORPORATION (US) 1989-10-19 WO disclosed
EP-0260299-A4 MUTAGENESIS AND SCREENING METHOD AND PRODUCT. GENEX CORP (US) 1988-11-24 EP disclosed
US-4760025-A Modified enzymes and methods for making same GENENCOR, INC. (US) 1988-07-26 US disclosed
EP-0260299-A1 MUTAGENESIS AND SCREENING METHOD AND PRODUCT Enzon Labs Inc. (US) 1988-03-23 EP disclosed
EP-0247647-A1 DNA mutagenesis method GENENTECH, INC. (US) 1987-12-02 EP disclosed
EP-0246678-A1 Bacillus incapable of excreting subtilisin or neutral protease GENENCOR INTERNATIONAL, INC. (US) 1987-11-25 EP disclosed
WO-1987005050-A1 MUTAGENESIS AND SCREENING METHOD AND PRODUCT GENEX CORPORATION (US) 1987-08-27 WO disclosed
EP-0130756-A1 Procaryotic carbonyl hydrolases, methods, DNA, vectors and transformed hosts for producing them, and detergent compositions containing them GENENCOR INTERNATIONAL, INC. (US) 1985-01-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260098231-A1 DETERGENT COMPOSITIONS, POLYMERS AND METHODS OF MANUFACTURING THE SAME SGMS2, SGMS1, PHOSPHO1 TACR1 4282/4885FKBP4 4683/4885PSMB9 311/4885
US-12576140-B2 Cyclophilin 40 for reduction of neurotoxic fibrils and treatment of neurodegenerative diseases PSEN1, PSEN2, PRNP TACR1 3837/4885FKBP4 122/4885PSMB9 3590/4885
US-12606610-B2 Compositions and methods for treatment of Netherton Syndrome with LEKTI expressing recombinant microbes CUTA, TMPRSS11D, KLK5 TACR1 4542/4885FKBP4 1922/4885PSMB9 513/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.