Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | NNMT | P40261 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184601 | 0.82 | GAA (0.52) | ALDH1A1TDP1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL12436753 | 0.80 | LMNA (0.53) | ALDH1A1TDP1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10783151 | 0.78 | LMNA (0.53) | ALDH1A1KMT2AMEN1LMNATSHR | |
| SCHEMBL1569200 | 0.78 | ALDH1A1 (0.54) | ALDH1A1L3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL1860285 | 0.76 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL17316533 | 0.76 | ALDH1A1 (0.53) | ALDH1A1L3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL17316607 | 0.76 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL2271144 | 0.76 | L3MBTL1 (0.66) | ALDH1A1L3MBTL1TDP1KMT2AMEN1 | |
| SCHEMBL3551388 | 0.76 | HDAC1 (0.60) | HDAC1 | |
| SCHEMBL634581 | 0.75 | ALDH1A1 (0.65) | ALDH1A1L3MBTL1TDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4665073-A | HISTAMINE H2-ANTAGONISTS | ICI AMERICAS INC. (GB) | 1987-05-12 | — | — | US | disclosed |
| EP-0060094-B1 | GUANIDINE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-22 | — | — | EP | disclosed |
| US-4447441-A | ANTIHISTAMINE, ANTIULCER AND ANTISECRETORY AGENT | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-05-08 | — | — | US | disclosed |
| EP-0060094-A2 | Guanidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-09-15 | — | — | EP | disclosed |