Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10789840 | 0.81 | MAPK1 (0.54) | ESR1ESR2TSHRALDH1A1MEN1 | |
| SCHEMBL10889247 | 0.74 | MAPT (0.45) | ALDH1A1MEN1KMT2AMAPTTP53 | |
| SCHEMBL11715994 | 0.74 | CES2 (0.54) | ESR1ESR2TSHRMEN1KMT2A | |
| SCHEMBL10886087 | 0.73 | EBP (0.57) | ESR1ESR2MEN1KMT2AMAPT | |
| SCHEMBL7488057 | 0.73 | MAPK1 (0.64) | ESR1ESR2TSHRMEN1KMT2A | |
| SCHEMBL10885086 | 0.72 | KDM4E (0.51) | ESR1MEN1KMT2AMAPTTP53 | |
| SCHEMBL16950997 | 0.72 | ERCC5 (0.49) | ALDH1A1MEN1KMT2AMAPTPARP1 | |
| SCHEMBL11718606 | 0.72 | HTT (0.49) | TSHRALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14101854 | 0.71 | PARP1 (0.47) | TSHRALDH1A1MAPTPARP1HPGD | |
| SCHEMBL2015776 | 0.71 | MAOA (0.48) | TSHRALDH1A1MAPTPARP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112588-B1 | 4-HYDROXY-ALPHA-ETHYL BENZHYDROLES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1987-11-11 | — | — | EP | disclosed |
| EP-0112588-A2 | 4-Hydroxy-alpha-ethyl benzhydroles, process for their preparation and medicines containing these compounds | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1984-07-04 | — | — | EP | disclosed |