SCHEMBL10789975

SCHEMBL10789975

O=c1oc2c(O)cccc2c(F)c1F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 10/20 0.50
EGFR P00533 1/20 0.50
ATP1A1 P05023 2/20 0.49
ATP1B1 P05026 2/20 0.49
ATP1A3 P13637 2/20 0.49
ATP1B2 P14415 2/20 0.49
ATP1A2 P50993 2/20 0.49
ATP1B3 P54709 2/20 0.49
FXYD2 P54710 2/20 0.49
ATP1A4 Q13733 2/20 0.49
LOXL2 Q9Y4K0 1/20 0.44
ADORA3 P0DMS8 3/20 0.42
ADORA2A P29274 3/20 0.42
ADORA1 P30542 3/20 0.42
MAOB P27338 2/20 0.42
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42
ESR2 Q92731 4/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10794106 0.84 HSD17B3 (0.50) MAOAEGFRATP1A1ATP1B1ATP1A3
SCHEMBL10791553 0.84 ESR2 (0.48) MAOAEGFRATP1A1ATP1B1ATP1A3
SCHEMBL8492619 0.77 ATP1A1 (0.56) MAOAEGFRATP1A1ATP1B1ATP1A3
SCHEMBL26779869 0.77 ESR2 (0.64) MAOAEGFRATP1A1ATP1B1ATP1A3
SCHEMBL10789961 0.76 ESR2 (0.53) MAOAEGFRATP1A1ATP1B1ATP1A3
SCHEMBL26779741 0.76 MAOA (0.61) MAOAEGFRATP1A1ATP1B1ATP1A3
SCHEMBL10846874 0.74 MAOA (0.50) MAOAEGFRATP1A1ATP1B1ATP1A3
SCHEMBL10791657 0.74 MAOA (0.50) MAOAEGFRATP1A1ATP1B1ATP1A3
SCHEMBL12359896 0.74 MAOA (0.69) MAOAEGFRATP1A1ATP1B1ATP1A3
SCHEMBL7228336 0.74 ATP1A1 (0.79) MAOAEGFRATP1A1ATP1B1ATP1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0111746-B1 SULFONIC-ACID ESTERS OF HYDROXYCOUMARINES, THEIR PREPARATION AND MEDICINES CONTAINING THEM BASF Aktiengesellschaft (DE) 1987-09-16 EP disclosed
US-4618622-A ANTIDEPRESSANTS, ANTIALLERGENS BASF AKTIENGESELLSCHAFT (DE) 1986-10-21 US disclosed
EP-0111746-A2 Sulfonic-acid esters of hydroxycoumarines, their preparation and medicines containing them BASF Aktiengesellschaft (DE) 1984-06-27 EP disclosed