Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL933202 | 0.97 | CYP1A2 (0.33) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| SCHEMBL933207 | 0.96 | CYP1A2 (0.33) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| Hydrochloric Acid SCHEMBL1070862 | 0.85 | KDM4E (0.34) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL1070626 | 0.83 | KDM4E (0.34) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL1071433 | 0.81 | ALDH1A1 (0.35) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| SCHEMBL7752375 | 0.81 | KDM4E (0.35) | ALDH1A1KDM4EALOX15TSHRACMSD | |
| Hydrochloric Acid SCHEMBL1071457 | 0.78 | ALDH1A1 (0.35) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| SCHEMBL5176456 | 0.77 | CYP1A2 (0.33) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| SCHEMBL3875700 | 0.77 | CYP1A2 (0.33) | ALDH1A1CYP1A2KDM4EALOX15TSHR | |
| Hydrochloric Acid SCHEMBL5078576 | 0.76 | ALDH1A1 (0.33) | ALDH1A1CYP1A2KDM4EALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513166-B1 | PROCESS FOR THE PREPARATION OF SUPPORTED CATALYSTS | BASELL POLYOLEFINE GMBH (DE) | 2017-04-05 | — | — | EP | disclosed |
| EP-2134756-B1 | CATALYST COMPOSITION AND POLYMERISATION PROCESS USING IT | BASELL POLYOLEFINE GMBH (DE) | 2015-06-10 | — | — | EP | disclosed |
| US-8859451-B2 | Process for the preparation of supported catalysts | BASELL POLYOLEFINE GMBH (DE) | 2014-10-14 | — | — | US | disclosed |
| US-8759460-B2 | Process for the polymerization of ethylene, and ethylene polymers having broad molecular weight distribution and long-chain branching | BASSELL POLYOLEFINE GMBH (DE) | 2014-06-24 | — | — | US | disclosed |
| US-8563674-B2 | Polyethylene and catalyst composition for its preparation | BASELL POLYOLEFINE GMBH (DE) | 2013-10-22 | — | — | US | disclosed |
| EP-2225283-B1 | MULTISTAGE PROCESS FOR THE POLYMERIZATION OF OLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2013-08-14 | — | — | EP | disclosed |
| EP-2177543-B1 | Hybrid catalyst composition for polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2013-08-14 | — | — | EP | disclosed |
| US-8501884-B2 | Polyethylene and catalyst composition and process for the preparation thereof | BASELL POLYOLEFINE GMBH (DE) | 2013-08-06 | — | — | US | disclosed |
| US-8435911-B2 | Hybrid catalyst composition for polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2013-05-07 | — | — | US | disclosed |
| EP-2356155-B1 | PROCESS FOR THE POLYMERIZATION OF ETHYLENE, AND ETHYLENE POLYMERS HAVING BROAD MOLECULAR WEIGHT DISTRIBUTION AND LONG- CHAIN BRANCHING | BASELL POLYOLEFINE GMBH (DE) | 2013-01-23 | — | — | EP | disclosed |
| EP-2225283-A1 | MULTISTAGE PROCESS FOR THE POLYMERIZATION OF OLEFINS | Basell Polyolefine GmbH (DE) | 2010-09-08 | — | — | EP | disclosed |
| US-7767613-B2 | Polyethylene and catalyst composition for its preparation | BASELL POLYOLEFINE GMBH (DE) | 2010-08-03 | — | — | US | disclosed |
| WO-2010063432-A1 | PROCESS FOR THE POLYMERIZATION OF ETHYLENE, AND ETHYLENE POLYMERS HAVING BROAD MOLECULAR WEIGHT DISTRIBUTION AND LONG- CHAIN BRANCHING | BASELL POLYOLEFINE GMBH (DE) | 2010-06-10 | — | — | WO | disclosed |
| US-20100099825-A1 | Hybrid catalyst composition for polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2010-04-22 | — | — | US | disclosed |
| EP-2177543-A1 | Hybrid catalyst composition for polymerization of olefins | Basell Polyolefine GmbH (DE) | 2010-04-21 | — | — | EP | disclosed |
| US-20100093956-A1 | POLYETHYLENE AND CATALYST COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF | BASELL POLYOLEFINE GMBH (DE) | 2010-04-15 | — | — | US | disclosed |
| WO-2009080359-A1 | MULTISTAGE PROCESS FOR THE POLYMERIZATION OF OLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2009-07-02 | — | — | WO | disclosed |
| US-20080027192-A1 | Process for Preparing Catalyst Systems Comprising Late Transition Metals | BASELL POLYOLEFINE GMBH (DE) | 2008-01-31 | — | — | US | disclosed |
| EP-1817349-A1 | PROCESS FOR PREPARING CATALYST SYSTEMS COMPRISING LATE TRANSITION METALS | Basell Polyolefine GmbH (DE) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006058746-A1 | PROCESS FOR PREPARING CATALYST SYSTEMS COMPRISING LATE TRANSITION METALS | BASELL POLYOLEFINE GMBH (DE) | 2006-06-08 | — | — | WO | disclosed |