Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1070626 | 0.97 | KDM4E (0.34) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL7752375 | 0.96 | KDM4E (0.35) | KDM4EALOX15TSHRACMSDTDP1 | |
| Hydrochloric Acid SCHEMBL1078463 | 0.87 | KDM4E (0.34) | KDM4EALOX15TSHRACMSDTDP1 | |
| Hydrochloric Acid SCHEMBL1079384 | 0.85 | ALDH1A1 (0.35) | KDM4EALOX15TSHRACMSDTDP1 | |
| Hydrochloric Acid SCHEMBL1071561 | 0.84 | KDM4E (0.34) | KDM4EALOX15TSHRACMSDTDP1 | |
| Bromide SCHEMBL933202 | 0.83 | CYP1A2 (0.33) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL933207 | 0.81 | CYP1A2 (0.33) | KDM4EALOX15TSHRACMSDTDP1 | |
| Hydrochloric Acid SCHEMBL2047916 | 0.78 | ALDH1A1 (0.33) | KDM4EALOX15TSHRACMSDTDP1 | |
| Hydrochloric Acid SCHEMBL5082319 | 0.74 | ALDH1A1 (0.34) | KDM4EALOX15TSHRACMSDTDP1 | |
| Hydrochloric Acid SCHEMBL5077945 | 0.74 | ALDH1A1 (0.34) | KDM4EALOX15TSHRACMSDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 81 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513166-B1 | PROCESS FOR THE PREPARATION OF SUPPORTED CATALYSTS | BASELL POLYOLEFINE GMBH (DE) | 2017-04-05 | — | — | EP | disclosed |
| EP-2134756-B1 | CATALYST COMPOSITION AND POLYMERISATION PROCESS USING IT | BASELL POLYOLEFINE GMBH (DE) | 2015-06-10 | — | — | EP | disclosed |
| US-8859451-B2 | Process for the preparation of supported catalysts | BASELL POLYOLEFINE GMBH (DE) | 2014-10-14 | — | — | US | disclosed |
| US-8759460-B2 | Process for the polymerization of ethylene, and ethylene polymers having broad molecular weight distribution and long-chain branching | BASSELL POLYOLEFINE GMBH (DE) | 2014-06-24 | — | — | US | disclosed |
| US-8563674-B2 | Polyethylene and catalyst composition for its preparation | BASELL POLYOLEFINE GMBH (DE) | 2013-10-22 | — | — | US | disclosed |
| EP-2177543-B1 | Hybrid catalyst composition for polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2013-08-14 | — | — | EP | disclosed |
| EP-2225283-B1 | MULTISTAGE PROCESS FOR THE POLYMERIZATION OF OLEFINS | BASELL POLYOLEFINE GMBH (DE) | 2013-08-14 | — | — | EP | disclosed |
| US-8501884-B2 | Polyethylene and catalyst composition and process for the preparation thereof | BASELL POLYOLEFINE GMBH (DE) | 2013-08-06 | — | — | US | disclosed |
| US-8435911-B2 | Hybrid catalyst composition for polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2013-05-07 | — | — | US | disclosed |
| EP-2356155-B1 | PROCESS FOR THE POLYMERIZATION OF ETHYLENE, AND ETHYLENE POLYMERS HAVING BROAD MOLECULAR WEIGHT DISTRIBUTION AND LONG- CHAIN BRANCHING | BASELL POLYOLEFINE GMBH (DE) | 2013-01-23 | — | — | EP | disclosed |
| WO-2005058983-A2 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2005-06-30 | — | — | WO | disclosed |
| EP-1539774-A1 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2005-06-15 | — | — | EP | disclosed |
| EP-1534724-A2 | MONOCYCLOPENTADIENYL COMPLEXES | Basell Polyolefine GmbH (DE) | 2005-06-01 | — | — | EP | disclosed |
| US-20040249095-A1 | Method of polymerization of olefins | BASELL POLYOLEFINE GMBH (DE) | 2004-12-09 | — | — | US | disclosed |
| WO-2004104052-A1 | TRANSITION-METAL COMPLEXES WITH TRIDENTATE, NITROGEN-CONTAINING LIGANDS | BASELL POLYOLEFINE GMBH (DE) | 2004-12-02 | — | — | WO | disclosed |
| US-20040242880-A1 | Monocyclopentadienyl complexes comprising a condensed heterocycle | BASELL POLYOLEFINE GMBH (DE) | 2004-12-02 | — | — | US | disclosed |
| WO-2004056482-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-07-08 | — | — | WO | disclosed |
| WO-2004056481-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-07-08 | — | — | WO | disclosed |
| WO-2004020479-A2 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-03-11 | — | — | WO | disclosed |
| WO-2004018489-A1 | MONOCYCLOPENTADIENYL COMPLEXES | BASELL POLYOLEFINE GMBH (DE) | 2004-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242880-A1 | Monocyclopentadienyl complexes comprising a condensed heterocycle | MCM4, MCM3, CCNC | KDM4E 3332/4885ALOX15 1095/4885TSHR 4863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.