Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 2/20 | 0.49 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 12/20 | 0.40 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10800551 | 0.88 | APLNR (0.39) | APLNRHTR6CXCR2CX3CR1CHRNB2 | |
| SCHEMBL10798768 | 0.87 | APLNR (0.46) | APLNRCXCR2CX3CR1 | |
| SCHEMBL10798781 | 0.87 | APLNR (0.38) | APLNRHTR6CXCR2CX3CR1 | |
| SCHEMBL10797771 | 0.86 | HTR6 (0.50) | APLNRHTR6CXCR2CX3CR1 | |
| Hydrochloric Acid SCHEMBL10799725 | 0.85 | APLNR (0.37) | APLNRHTR6CXCR2CX3CR1 | |
| SCHEMBL10795117 | 0.85 | APLNR (0.47) | APLNRHTR6CXCR2CX3CR1HTR3A | |
| Hydrochloric Acid SCHEMBL10799498 | 0.85 | HTR6 (0.49) | APLNRHTR6CXCR2CX3CR1 | |
| SCHEMBL10797838 | 0.81 | CYP2D6 (0.47) | APLNRCXCR2CX3CR1 | |
| SCHEMBL16771112 | 0.79 | GABRA1 (0.42) | HTR6CXCR2 | |
| SCHEMBL10799788 | 0.78 | APLNR (0.44) | APLNRHTR6CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4642348-A | ANTIARRHYTHMIA AGENTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1987-02-10 | — | — | US | disclosed |
| US-4593102-A | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position | A. H. ROBINS COMPANY, INC. (US) | 1986-06-03 | — | — | US | disclosed |
| EP-0160436-A2 | N-[(Amino)Alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulphur linked substitution in the 2, 3 or 4-position | A.H. ROBINS COMPANY, INCORPORATED (US) | 1985-11-06 | — | — | EP | disclosed |