Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | HRH1 | P35367 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9540017 | 0.83 | PKM (0.54) | PKMSMN1; SMN2LMNAALDH1A1NPSR1 | |
| SCHEMBL9564855 | 0.83 | USP2 (0.49) | SMN1; SMN2LMNAALDH1A1USP2ALOX15 | |
| SCHEMBL8565877 | 0.82 | HSD11B1 (0.46) | PKMSMN1; SMN2LMNAALDH1A1NPSR1 | |
| SCHEMBL9535390 | 0.81 | PKM (0.50) | PKMSMN1; SMN2LMNAALDH1A1NPSR1 | |
| SCHEMBL9537130 | 0.77 | KCNH2 (0.63) | SMN1; SMN2LMNAALDH1A1NPSR1TBXA2R | |
| SCHEMBL9536849 | 0.76 | HRH1 (0.62) | SMN1; SMN2LMNAALDH1A1NPSR1USP2 | |
| SCHEMBL9535641 | 0.76 | SSTR5 (0.52) | SMN1; SMN2LMNAALDH1A1NPSR1USP2 | |
| SCHEMBL10795380 | 0.74 | PKM (0.56) | PKMSMN1; SMN2LMNAALDH1A1HTT | |
| SCHEMBL9537373 | 0.73 | TP53 (0.52) | SMN1; SMN2LMNAALDH1A1NPSR1GAA | |
| SCHEMBL9536631 | 0.72 | SSTR5 (0.48) | SMN1; SMN2LMNAUSP2HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |