Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL2538043 | 0.87 | — | — | |
| Isopropyl Alcohol SCHEMBL8059212 | 0.87 | — | — | |
| Isopropyl Alcohol SCHEMBL9306830 | 0.87 | ALDH1A1 (0.47) | TDP1ALDH1A1TSHROR51E2TP53 | |
| Propylene Glycol SCHEMBL28916411 | 0.85 | TDP1 (0.59) | TDP1ALDH1A1TSHROR51E2TP53 | |
| Propylene Glycol SCHEMBL5804824 | 0.85 | TDP1 (0.59) | TDP1ALDH1A1TSHROR51E2TP53 | |
| Propylene Glycol SCHEMBL358822 | 0.84 | TDP1 (0.67) | TDP1ALDH1A1TSHROR51E2TP53 | |
| Butanedione SCHEMBL15009665 | 0.84 | TDP1 (0.67) | TDP1ALDH1A1TSHROR51E2TP53 | |
| Propylene Glycol SCHEMBL36041 | 0.84 | — | — | |
| Propylene Glycol SCHEMBL21828462 | 0.84 | TDP1 (0.67) | TDP1ALDH1A1TSHROR51E2TP53 | |
| Propylene Glycol SCHEMBL49092 | 0.84 | TDP1 (0.67) | TDP1ALDH1A1TSHROR51E2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109851473-B | Method for preparing 1,3-propylene glycol by hydrogenolysis of glycerol solution | 华东理工大学 | 2022-11-25 | — | — | CN | disclosed |
| US-9051588-B2 | Microorganisms and methods for production of 1,2-propanediol and acetol | METABOLIC EXPLORER (FR) | 2015-06-09 | — | — | US | disclosed |
| WO-2013134220-A1 | ELECTROCATALYTIC HYDROGENATION AND HYDRODEOXYGENATION OF OXYGENATED AND UNSATURATED ORGANIC COMPOUNDS | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2013-09-12 | — | — | WO | disclosed |
| CN-101641444-B | Microorganisms and methods for production of 1,2-propanediol and acetol | METABOLIC EXPLORER SA | 2013-08-07 | — | — | CN | disclosed |
| CN-101410361-B | Method of producing lower alcohols from glycerol | UNIV MISSOURI | 2013-05-08 | — | — | CN | disclosed |
| US-8298807-B2 | Micro-organisms for the production of 1,2-propanediol obtained by a combination of evolution and rational design | METABOLIC EXPLORER (FR) | 2012-10-30 | — | — | US | disclosed |
| US-20110262980-A1 | MICRO-ORGANISMS FOR THE PRODUCTION OF ACETOL OBTAINED BY A COMBINATION OF EVOLUTION AND RATIONAL DESIGN | METABOLIC EXPLORER (FR) | 2011-10-27 | — | — | US | disclosed |
| US-20110201070-A1 | MICROORGANISMS AND METHODS FOR PRODUCTION OF 1,2-PROPANEDIOL AND ACETOL | METABOLIC EXPLORER (FR) | 2011-08-18 | — | — | US | disclosed |
| CN-101990529-A | Method of producing lower alcohols from glycerol | UNIV MISSOURI BOARD OF CURATOR | 2011-03-23 | — | — | CN | disclosed |
| CN-101978052-A | Polypeptides having glyoxalase III activity, polynucleotides encoding same, and uses thereof | METABOLIC EXPLORER SA | 2011-02-16 | — | — | CN | disclosed |
| US-20110014666-A1 | POLYPEPTIDE HAVING GLYOXALASE III ACTIVITY, POLYNUCLEOTIDE ENCODING THE SAME AND USES THEREOF | METABOLIC EXPLORER (FR) | 2011-01-20 | — | — | US | disclosed |
| US-20100285547-A1 | NEW MICRO-ORGANISMS FOR THE PRODUCTION OF 1,2-PROPANEDIOL OBTAINED BY A COMBINATION OF EVOLUTION AND RATIONAL DESIGN | Metalbolic Explorer (FR) | 2010-11-11 | — | — | US | disclosed |
| US-20100261239-A1 | METABOLICALLY ENGINEERED MICROORGANISM USEFUL FOR THE PRODUCTION OF 1,2-PROPANEDIOL | Metalbolic Explorer (FR) | 2010-10-14 | — | — | US | disclosed |
| CN-101679940-A | Metabolically engineered microorganism useful for the production of 1,2-propanediol | METABOLIC EXPLORER SA | 2010-03-24 | — | — | CN | disclosed |
| CN-101641444-A | Microorganisms and methods for production of 1,2-propanediol and acetol | METABOLIC EXPLORER SA FR | 2010-02-03 | — | — | CN | disclosed |
| CN-101641446-A | Novel microorganisms for the production of 1, 2-propanediol obtained by a combination of evolution and rational design | METABOLIC EXPLORER SA FR | 2010-02-03 | — | — | CN | disclosed |
| CN-101410361-A | Method of producing lower alcohols from glycerol | UNIV MISSOURI BOARD OF CURATOR (US) | 2009-04-15 | — | — | CN | disclosed |