Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.55 |
| ▸ | GRM7 | Q14831 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10421952 | 0.78 | MAPT (0.71) | MAPTMTNR1AMTNR1BGRM7HRH3 | |
| SCHEMBL10800942 | 0.77 | ALDH1A1 (0.52) | HPGDTSHR | |
| SCHEMBL4858101 | 0.76 | MAPT (0.69) | MAPTMTNR1AMTNR1BGRM7IDO1 | |
| SCHEMBL10804933 | 0.76 | MAPT (0.69) | MAPTMTNR1AMTNR1BGRM7TSHR | |
| SCHEMBL6359193 | 0.76 | MTNR1A (0.79) | MAPTMTNR1AMTNR1BGRM7TSHR | |
| SCHEMBL10804577 | 0.75 | ALDH1A1 (0.63) | HPGDTSHR | |
| SCHEMBL1193095 | 0.74 | MAPT (0.91) | MAPTMTNR1AMTNR1BGRM7HPGD | |
| SCHEMBL30595323 | 0.73 | MTNR1A (0.77) | MAPTMTNR1AMTNR1BGRM7IDO1 | |
| SCHEMBL1029693 | 0.73 | MTNR1A (0.77) | MAPTMTNR1AMTNR1BGRM7IDO1 | |
| SCHEMBL13638135 | 0.73 | SMN1; SMN2 (0.56) | MAPTHPGDTSHRHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0159254-B1 | DERIVATIVES OF OMEGA-MERCAPTOPROPANAMIDE AND THEIR SALTS, THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1987-10-07 | — | — | EP | disclosed |
| EP-0159254-A1 | Derivatives of omega-mercaptopropanamide and their salts, their preparation, their use as medicines and compositions containing them | ROUSSEL-UCLAF (FR) | 1985-10-23 | — | — | EP | disclosed |