SCHEMBL10801092

SCHEMBL10801092

Cc1cccc(C(Br)(Br)Br)c1Br

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 2/20 0.41
GABRB2 P47870 2/20 0.41
ALDH1A1 P00352 5/20 0.40
CYP2A6 P11509 2/20 0.38
CYP1A2 P05177 1/20 0.38
TRPA1 O75762 2/20 0.37
ATM Q13315 1/20 0.37
TSHR P16473 1/20 0.36
ACHE P22303 1/20 0.36
CA2 P00918 2/20 0.36
CA1 P00915 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
HCAR1 Q9BXC0 1/20 0.33
CD44 P16070 1/20 0.32
MAPK1 P28482 1/20 0.32
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12253731 0.83 GABRA1 (0.56) GABRA1GABRB2ALDH1A1CYP2A6CYP1A2
SCHEMBL10658090 0.81 GABRA1 (0.39) GABRA1GABRB2ALDH1A1CYP2A6CYP1A2
SCHEMBL29932856 0.81 TAS2R14 (0.40) GABRA1GABRB2ALDH1A1CYP2A6CYP1A2
SCHEMBL8118306 0.81 TAS2R14 (0.40) GABRA1GABRB2ALDH1A1CYP2A6CYP1A2
SCHEMBL16379353 0.79 GABRA1 (0.47) GABRA1GABRB2ALDH1A1CYP2A6CYP1A2
SCHEMBL8164803 0.78 ALDH1A1 (0.53) GABRA1GABRB2ALDH1A1CYP2A6CYP1A2
SCHEMBL62013 0.78
Cyanide SCHEMBL27932755 0.76 ALDH1A1 (0.46) GABRA1GABRB2ALDH1A1CYP2A6CYP1A2
SCHEMBL12925871 0.76 TSHR (0.50) GABRA1GABRB2ALDH1A1CYP2A6CYP1A2
SCHEMBL126987 0.75 ALDH1A1 (0.50) GABRA1GABRB2ALDH1A1CYP2A6CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4694057-A Preparation of polymers containing pendant isocyanate groups and derivatives thereof by emulsion copolymerization THE GOODYEAR TIRE & RUBBER COMPANY (US) 1987-09-15 US disclosed
EP-0194222-A2 Preparation of polymers containing pendant isocyanate groups and derivatives thereof by emulsion copolymerization THE GOODYEAR TIRE & RUBBER COMPANY (US) 1986-09-10 EP disclosed
US-4288607-A USEFUL IN UNSATURATED POLYESTERS AND AS FIRE RETARDANTS DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1981-09-08 US disclosed
US-4212996-A USING AN IRON OR ALUMINUM MASKING (COMPLEXING) AGENT CONTAINING AMINOACETIC ACID GROUPS DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1980-07-15 US disclosed
US-4152511-A FIRE-RETARDANT MOLDING MATERIALS CONTAINING CHLORINE OR BROMINE DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1979-05-01 US disclosed
US-4119612-A Polymeric and oligomeric formals DYNAMIT NOBEL AKTIENGESELLSCHAFT (DE) 1978-10-10 US disclosed
US-4107104-A TETRABROMOXYLENEDIOL - FLAME-RETARDANT FOR POLYURETHANES ETHYL CORPORATION (US) 1978-08-15 US disclosed
US-3947494-A HEAVY METAL CATALYST, OXIDATION OF XYLENES STANDARD OIL COMPANY (US) 1976-03-30 US disclosed