Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11015128 | 0.81 | ALDH1A1 (0.40) | ALDH1A1GAAKDM4ENPC1HPGD | |
| SCHEMBL10805519 | 0.80 | GAA (0.32) | GAAKDM4ENPC1MAPTL3MBTL1 | |
| SCHEMBL15327693 | 0.72 | NOTUM (0.33) | GAAKDM4ENPC1HPGDL3MBTL1 | |
| Hydrochloric Acid SCHEMBL10800905 | 0.70 | CFTR (0.37) | HPGDL3MBTL1ATM | |
| SCHEMBL11358616 | 0.69 | GAA (0.41) | ALDH1A1GAAKDM4ENPC1HPGD | |
| SCHEMBL10430053 | 0.67 | KDM4E (0.44) | ALDH1A1GAAKDM4ENPC1HPGD | |
| SCHEMBL11353190 | 0.66 | KMT2A (0.36) | CA12CA2CA14MAPTL3MBTL1 | |
| SCHEMBL10430074 | 0.64 | ALDH1A1 (0.47) | ALDH1A1GAAKDM4ENPC1HPGD | |
| SCHEMBL11553522 | 0.63 | ALDH1A1 (0.46) | ALDH1A1GAAKDM4ENPC1HPGD | |
| SCHEMBL9505292 | 0.63 | CUL4A (0.36) | ALDH1A1GAAKDM4ECA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0103142-B1 | THIENO(2,3-E)-1,2-THIAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-04-22 | — | — | EP | disclosed |
| EP-0103142-A1 | Thieno(2,3-e)-1,2-thiazine derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-03-21 | — | — | EP | disclosed |