Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | BCR | P11274 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.46 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30979899 | 0.88 | ABL1 (0.63) | PTGS1ABL1ABCB1BCRNFE2L2 | |
| SCHEMBL1514434 | 0.88 | ABL1 (0.63) | PTGS1ABL1ABCB1BCRNFE2L2 | |
| SCHEMBL10800839 | 0.84 | ABL1 (0.50) | ABL1ABCB1BCRNFE2L2SYK | |
| SCHEMBL10802577 | 0.82 | ABL1 (0.61) | ABL1ABCB1BCRBACE1HDAC4 | |
| SCHEMBL8218517 | 0.80 | MDM2 (0.51) | PTGS1CYP1A1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL15624598 | 0.78 | NFE2L2 (0.59) | PTGS1ABL1ABCB1BCRNFE2L2 | |
| SCHEMBL1816063 | 0.78 | CYP1A1 (0.54) | PTGS1NFE2L2RELATUBB4ATUBB | |
| SCHEMBL1615072 | 0.77 | ABL1 (0.63) | ABL1ABCB1BCRBACE1CYP1A1 | |
| SCHEMBL16428843 | 0.77 | CYP1A1 (0.53) | PTGS1NFE2L2RELATUBB4ATUBB | |
| SCHEMBL20886677 | 0.76 | APP (0.56) | ABL1ABCB1BCRBACE1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0130045-B1 | TERPHENYL DERIVATIVES | ELI LILLY AND COMPANY (US) | 1987-01-21 | — | — | EP | claimed |
| EP-0130045-A1 | Terphenyl derivatives | ELI LILLY AND COMPANY (US) | 1985-01-02 | — | — | EP | claimed |
| EP-0130045-B1 | TERPHENYL DERIVATIVES | ELI LILLY AND COMPANY (US) | 1987-01-21 | — | — | EP | disclosed |
| US-4495202-A | ANALGESICS; ANTIPYRETICS; ANTICOAGULANTS; ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1985-01-22 | — | — | US | disclosed |
| EP-0130045-A1 | Terphenyl derivatives | ELI LILLY AND COMPANY (US) | 1985-01-02 | — | — | EP | disclosed |