Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | AHCY | P23526 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 2/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1067071 | 1.00 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL1067067 | 1.00 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AL3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL1082148 | 0.98 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL2660633 | 0.81 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL2151487 | 0.80 | DNM1 (0.43) | ALDH1A1MEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL2158567 | 0.80 | DNM1 (0.43) | ALDH1A1MEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL2660802 | 0.80 | MAPT (0.38) | ALDH1A1MEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL24884401 | 0.79 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AL3MBTL1TDP1 | |
| SCHEMBL12200444 | 0.78 | NOS1 (0.39) | ALDH1A1L3MBTL1CSNK2A1ADRA2AADRA2B | |
| SCHEMBL2669048 | 0.78 | NOS1 (0.39) | ALDH1A1L3MBTL1CSNK2A1ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274297-B1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2012-05-09 | — | — | EP | claimed |
| US-7741327-B2 | Pyrrolidinone glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2010-06-22 | — | — | US | claimed |
| US-20090264445-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | BERTHEL STEVEN JOSEPH | 2009-10-22 | — | — | US | claimed |
| US-8697705-B2 | Isoindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2014-04-15 | — | — | US | disclosed |
| EP-2705033-A1 | ISOINDOLINONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2014-03-12 | — | — | EP | disclosed |
| US-20130296339-A1 | ISOINDOLINONE DERIVATIVES | HOFFMANN LA ROCHE (US) | 2013-11-07 | — | — | US | disclosed |
| US-8470866-B2 | Isoindolinone derivatives | HOFFMANN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | disclosed |
| WO-2012150202-A1 | ISOINDOLINONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-08 | — | — | WO | disclosed |
| US-20120283271-A1 | ISOINDOLINONE DERIVATIVES | BERTHEL STEVEN JOSEPH (US) | 2012-11-08 | — | — | US | disclosed |
| EP-2274297-B1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | HOFFMANN LA ROCHE (CH) | 2012-05-09 | — | — | EP | disclosed |
| US-7935699-B2 | Pyrazole glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2011-05-03 | — | — | US | disclosed |
| EP-2274297-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2011-01-19 | — | — | EP | disclosed |
| EP-2261216-A2 | Pyrazoles as glucokinase activators | F. Hoffmann-La Roche AG (CH) | 2010-12-15 | — | — | EP | disclosed |
| EP-2236498-A1 | PHENYL ACETAMIDE DERIVATIVE | Astellas Pharma Inc. (JP) | 2010-10-06 | — | — | EP | disclosed |
| US-7741327-B2 | Pyrrolidinone glucokinase activators | HOFFMANN-LA ROCHE INC. (US) | 2010-06-22 | — | — | US | disclosed |
| US-20090264445-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | BERTHEL STEVEN JOSEPH | 2009-10-22 | — | — | US | disclosed |
| WO-2009127546-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-22 | — | — | WO | disclosed |
| EP-2046755-A2 | PYRAZOLES AS GLUCOKINASE ACTIVATORS | F. Hoffmann-Roche AG (CH) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008012227-A2 | PYRAZOLES AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-01-31 | — | — | WO | disclosed |
| US-20080021032-A1 | Pyrazole glucokinase activators | BERTHEL STEVEN JOSEPH | 2008-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120283271-A1 | ISOINDOLINONE DERIVATIVES | GCK, GCKR, PDK2 | ALDH1A1 523/4885MEN1 3350/4885KMT2A 3130/4885 |
| US-20090264445-A1 | PYRROLIDINONE GLUCOKINASE ACTIVATORS | GCKR, GCK, PDK2 | ALDH1A1 1129/4885MEN1 2997/4885KMT2A 2072/4885 |
| US-20130296339-A1 | ISOINDOLINONE DERIVATIVES | GCK, GCKR, PDK2 | ALDH1A1 523/4885MEN1 3350/4885KMT2A 3130/4885 |
| US-20080021032-A1 | Pyrazole glucokinase activators | GCKR, GCK, GALK1 | ALDH1A1 1567/4885MEN1 4026/4885KMT2A 4296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.