Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | GABRP | O00591 | 1/20 | 0.45 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | GABRE | P78334 | 1/20 | 0.45 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.45 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.45 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.45 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.45 |
| ▸ | RORB | Q92753 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10806968 | 1.00 | RECQL (0.55) | RECQLGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10805120 | 0.88 | KCNMA1 (0.41) | RECQLMAPTALDH1A1LMNAAR | |
| SCHEMBL10805115 | 0.88 | KCNMA1 (0.41) | RECQLMAPTALDH1A1LMNAAR | |
| SCHEMBL10815111 | 0.85 | ALDH1A1 (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL10815106 | 0.85 | ALDH1A1 (0.49) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL852853 | 0.80 | ALDH1A1 (0.49) | GABRA1GABRG2GABRB3ALDH1A1AR | |
| SCHEMBL852854 | 0.80 | ALDH1A1 (0.49) | GABRA1GABRG2GABRB3ALDH1A1AR | |
| SCHEMBL11842389 | 0.76 | RECQL (0.77) | RECQLGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9851141 | 0.74 | RECQL (0.74) | RECQLGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10673014 | 0.72 | GABRA1 (0.51) | GABRA1GABRB1GABRG2GABRB3GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0094668-B1 | PYRROLE (3,4-D)(2)BENZAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-07-08 | — | — | EP | disclosed |
| EP-0045519-B1 | PYRROLO-(3,4-D)-BENZAPINES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-06-19 | — | — | EP | disclosed |
| US-4460781-A | PREPARATION OF PYRAZOLOBENZAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1984-07-17 | — | — | US | disclosed |
| US-4436662-A | SEDATIVES, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1984-03-13 | — | — | US | disclosed |
| US-4431823-A | SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1984-02-14 | — | — | US | disclosed |
| US-4428879-A | SEDATIVES, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1984-01-31 | — | — | US | disclosed |
| US-4428878-A | SEDATIVES, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1984-01-31 | — | — | US | disclosed |
| EP-0094668-A2 | Pyrrole (3,4-d)(2)benzazepine derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-11-23 | — | — | EP | disclosed |
| US-4409390-A | 3-(2-AMINOETHYL)-4-(2-HYDROXYBENZYL-PHENYL) PYRROLE INTERMEDIATE | HOFFMANN-LA ROCHE INC. (US) | 1983-10-11 | — | — | US | disclosed |
| US-4405518-A | SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-09-20 | — | — | US | disclosed |
| US-4379765-A | SEDATIVES, ANXIETY | HOFFMANN-LA ROCHE INC. (US) | 1983-04-12 | — | — | US | disclosed |
| US-4354973-A | SEDATIVES AND ANXIOLYTICS | HOFFMANN-LA ROCHE INC. (US) | 1982-10-19 | — | — | US | disclosed |
| EP-0045519-A2 | Pyrrolo-(3,4-d)-benzapines, process and intermediates for their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-02-10 | — | — | EP | disclosed |