Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | IDE | P14735 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10804730 | 0.78 | L3MBTL1 (0.53) | TDP1L3MBTL1NSD2ABL1GAA | |
| SCHEMBL10809390 | 0.76 | L3MBTL1 (0.46) | TDP1L3MBTL1NSD2ABL1GAA | |
| SCHEMBL10809384 | 0.72 | L3MBTL1 (0.43) | TDP1L3MBTL1NSD2ABL1GAA | |
| SCHEMBL10806845 | 0.69 | CYP3A4 (0.51) | TDP1L3MBTL1GAACYP1A2CYP2C9 | |
| SCHEMBL10804145 | 0.68 | L3MBTL1 (0.59) | TDP1L3MBTL1NSD2ABL1GAA | |
| SCHEMBL8075617 | 0.68 | — | — | |
| SCHEMBL28023546 | 0.67 | POLB (0.49) | TDP1L3MBTL1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL10804735 | 0.67 | NAAA (0.37) | TDP1L3MBTL1NSD2ABL1GAA | |
| SCHEMBL1515924 | 0.67 | CYP1A2 (0.44) | TDP1CYP1A2CYP2C9CYP2C19POLB | |
| SCHEMBL10811019 | 0.67 | NSD2 (0.50) | TDP1L3MBTL1NSD2ABL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079049-B1 | NOVEL SUBSTITUTED ALKANOYLIMIDAZOL-2-ONE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| US-4447619-A | CARDIOTONIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-05-08 | — | — | US | disclosed |
| EP-0079049-A2 | Novel substituted alkanoylimidazol-2-one derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-05-18 | — | — | EP | disclosed |
| US-4367236-A | CARDIOTONIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-01-04 | — | — | US | disclosed |