Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GALR3 | O60755 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11021626 | 0.85 | ALDH1A1 (0.42) | ALDH1A1KDM4EGAAHPGDGALR3 | |
| SCHEMBL7381624 | 0.79 | KDM4E (0.57) | ALDH1A1KDM4EGAAHPGDGALR3 | |
| SCHEMBL10810260 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAAHPGDGALR3 | |
| SCHEMBL10807248 | 0.77 | KDM4E (0.43) | ALDH1A1KDM4EGAAHPGDGALR3 | |
| SCHEMBL10747756 | 0.76 | ALDH1A1 (0.48) | ALDH1A1KDM4EGAAHPGDGALR3 | |
| SCHEMBL4514368 | 0.74 | KDM4E (0.50) | ALDH1A1KDM4EGAAHPGDGALR3 | |
| SCHEMBL4739455 | 0.74 | KDM4E (0.56) | ALDH1A1KDM4EGAAHPGDGALR3 | |
| SCHEMBL11021650 | 0.74 | PDE3B (0.42) | ALDH1A1KDM4EHPGDGALR3MEN1 | |
| SCHEMBL9770554 | 0.74 | PDE3A (0.59) | ALDH1A1KDM4EGAAHPGDGALR3 | |
| SCHEMBL10806794 | 0.74 | ALDH1A1 (0.50) | ALDH1A1KDM4EGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4650806-A | Cardiotonic 5-(heterylcarbonyl)-pyridones | STERLING DRUG INC. (US) | 1987-03-17 | — | — | US | disclosed |
| EP-0191298-A2 | 1,6 -Naphthyridin-2(1H) - ones useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1986-08-20 | — | — | EP | disclosed |
| US-4567186-A | 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof and intermediates therefor | STERLING DRUG INC. (US) | 1986-01-28 | — | — | US | disclosed |