Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 6/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10852619 | 0.90 | BAZ2B (0.45) | BAZ2BSIRT1HTR5AKIF11HDAC1 | |
| SCHEMBL10816136 | 0.89 | BAZ2B (0.42) | BAZ2BSIRT1KIF11HDAC1HDAC6 | |
| SCHEMBL10856311 | 0.87 | BAZ2B (0.43) | BAZ2BSIRT1KIF11HDAC1HDAC6 | |
| SCHEMBL10804195 | 0.87 | ABCB1 (0.38) | HTR5AHDAC1HDAC6KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL10851788 | 0.86 | ABCB1 (0.37) | HTR5AHDAC1HDAC6KDM4EMAPT | |
| SCHEMBL10858216 | 0.79 | KDM4E (0.42) | KIF11KDM4EGAAALDH1A1LMNA | |
| SCHEMBL10857236 | 0.79 | ABCB1 (0.38) | HTR5AHDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL10815637 | 0.77 | KDM4E (0.43) | KIF11KDM4EGAAALDH1A1LMNA | |
| SCHEMBL10818546 | 0.76 | ABCB1 (0.38) | HTR5AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11112919 | 0.76 | ABCB1 (0.36) | HTR5AHDAC1HDAC6KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0101574-B1 | 2-SUBSTITUTED 1-AMINOALKYL-1,2,3,4-TETRAHYDRO-BETA-CARBOLINES, THEIR PREPARATION AND USE AS MEDICAMENTS | BASF Aktiengesellschaft (DE) | 1987-02-04 | — | — | EP | disclosed |
| US-4575508-A | 2-Substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-β-carbolines, and their use as antiarrhythmic agents | BASF AKTIENGESELLSCHAFT (DE) | 1986-03-11 | — | — | US | disclosed |