Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 5/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | OXER1 | Q8TDS5 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10858216 | 0.90 | KDM4E (0.42) | KIF11MEN1KMT2A | |
| SCHEMBL10852619 | 0.90 | BAZ2B (0.45) | BAZ2BSIRT1KIF11HDAC1HDAC6 | |
| SCHEMBL10810544 | 0.89 | BAZ2B (0.43) | BAZ2BSIRT1TACR1KIF11HDAC1 | |
| SCHEMBL10856311 | 0.89 | BAZ2B (0.43) | BAZ2BSIRT1KIF11OXER1KMT2A | |
| SCHEMBL10808165 | 0.87 | TP53 (0.39) | HDAC1HDAC6 | |
| SCHEMBL11105995 | 0.84 | TP53 (0.39) | HDAC1HDAC6 | |
| SCHEMBL10815637 | 0.79 | KDM4E (0.43) | KIF11MEN1KMT2A | |
| SCHEMBL11112919 | 0.78 | ABCB1 (0.36) | HDAC1HDAC6 | |
| SCHEMBL10857924 | 0.78 | TP53 (0.38) | — | |
| SCHEMBL11113912 | 0.76 | EGFR (0.41) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0101574-B1 | 2-SUBSTITUTED 1-AMINOALKYL-1,2,3,4-TETRAHYDRO-BETA-CARBOLINES, THEIR PREPARATION AND USE AS MEDICAMENTS | BASF Aktiengesellschaft (DE) | 1987-02-04 | — | — | EP | disclosed |
| US-4575508-A | 2-Substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-β-carbolines, and their use as antiarrhythmic agents | BASF AKTIENGESELLSCHAFT (DE) | 1986-03-11 | — | — | US | disclosed |