Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 5/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 2/20 | 0.34 |
| ▸ | OXER1 | Q8TDS5 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10815637 | 0.90 | KDM4E (0.43) | KMT2AKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10852619 | 0.90 | BAZ2B (0.45) | BAZ2BSIRT1KDM4EGAAALDH1A1 | |
| SCHEMBL10816136 | 0.89 | BAZ2B (0.42) | BAZ2BSIRT1KMT2AKIF11OXER1 | |
| SCHEMBL10810544 | 0.87 | BAZ2B (0.43) | BAZ2BSIRT1KDM4EGAAALDH1A1 | |
| SCHEMBL10804503 | 0.87 | ABCB1 (0.40) | KDM4EGAAALDH1A1MAPTHDAC1 | |
| SCHEMBL10816796 | 0.84 | ABCB1 (0.39) | KDM4EGAAALDH1A1MAPT | |
| SCHEMBL10854756 | 0.83 | ABCB1 (0.40) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL11113912 | 0.80 | EGFR (0.41) | KMT2AKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10858216 | 0.79 | KDM4E (0.42) | KMT2AKDM4EGAAALDH1A1LMNA | |
| SCHEMBL10815996 | 0.78 | ABCB1 (0.39) | KDM4EGAAALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4575508-A | 2-Substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-β-carbolines, and their use as antiarrhythmic agents | BASF AKTIENGESELLSCHAFT (DE) | 1986-03-11 | — | — | US | disclosed |