Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | YAP1 | P46937 | 1/20 | 0.36 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10816136 | 0.90 | BAZ2B (0.42) | MEN1KMT2AKIF11 | |
| SCHEMBL10815637 | 0.89 | KDM4E (0.43) | KDM4EGAAHSD17B10USP2ALDH1A1 | |
| SCHEMBL10808165 | 0.88 | TP53 (0.39) | KDM4EMAPTRAB9A | |
| SCHEMBL11105995 | 0.85 | TP53 (0.39) | KDM4EMAPTRAB9A | |
| SCHEMBL10852619 | 0.79 | BAZ2B (0.45) | KDM4EGAAHSD17B10USP2ALDH1A1 | |
| SCHEMBL10857924 | 0.79 | TP53 (0.38) | KDM4EALDH1A1MAPTTHRBTSHR | |
| SCHEMBL10856311 | 0.79 | BAZ2B (0.43) | KDM4EGAAALDH1A1MAPTKMT2A | |
| SCHEMBL10810544 | 0.79 | BAZ2B (0.43) | KDM4EGAAHSD17B10USP2ALDH1A1 | |
| SCHEMBL11112919 | 0.79 | ABCB1 (0.36) | KDM4EMAPTRAB9A | |
| SCHEMBL11113912 | 0.77 | EGFR (0.41) | KDM4EGAAHSD17B10ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4575508-A | 2-Substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-β-carbolines, and their use as antiarrhythmic agents | BASF AKTIENGESELLSCHAFT (DE) | 1986-03-11 | — | — | US | disclosed |