Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10808457 | 1.00 | KDM4E (0.41) | KDM4ELMNAFFAR4PDE5AALDH1A1 | |
| SCHEMBL10809218 | 0.84 | NPC1 (0.42) | KDM4EFFAR4PDE5AALDH1A1POLB | |
| SCHEMBL10812031 | 0.83 | FFAR4 (0.44) | KDM4EFFAR4PDE5AALDH1A1POLB | |
| SCHEMBL10407970 | 0.81 | PDE5A (0.50) | KDM4ELMNAPDE5AALDH1A1POLB | |
| SCHEMBL10407972 | 0.81 | PDE5A (0.50) | KDM4ELMNAPDE5AALDH1A1POLB | |
| SCHEMBL10812819 | 0.78 | PDE5A (0.41) | KDM4ELMNAFFAR4PDE5AALDH1A1 | |
| SCHEMBL5688117 | 0.71 | KDM4E (0.76) | KDM4ELMNAALDH1A1APPMMP2 | |
| SCHEMBL5688120 | 0.71 | KDM4E (0.76) | KDM4ELMNAALDH1A1APPMMP2 | |
| SCHEMBL10974265 | 0.70 | PDE5A (0.53) | KDM4ELMNAPDE5AALDH1A1POLB | |
| SCHEMBL10974259 | 0.70 | PDE5A (0.53) | KDM4ELMNAPDE5AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079637-B1 | ANTI-SRS-A CARBOXYLIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL FORMULATION CONTAINING THEM | FISONS plc (GB) | 1987-01-28 | — | — | EP | disclosed |
| US-4474788-A | Anti-SRSA quinoline carboxylic acid derivatives | FISONS PLC (GB) | 1984-10-02 | — | — | US | disclosed |
| EP-0079637-A1 | Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them | FISONS plc (GB) | 1983-05-25 | — | — | EP | disclosed |