Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10810642 | 0.84 | KDM4E (0.41) | MAPTPDE5ACTSDKDM4EALDH1A1 | |
| SCHEMBL10808457 | 0.84 | KDM4E (0.41) | MAPTPDE5ACTSDKDM4EALDH1A1 | |
| SCHEMBL10812819 | 0.83 | PDE5A (0.41) | NPC1RAB9AMAPTSMN1; SMN2PDE5A | |
| SCHEMBL10812031 | 0.79 | FFAR4 (0.44) | MAPTPDE5AKDM4EALDH1A1POLB | |
| SCHEMBL10972035 | 0.76 | PDE5A (0.52) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL29957385 | 0.71 | NPC1 (0.48) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL10959657 | 0.69 | ERN1 (0.48) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL7046194 | 0.69 | SMN1; SMN2 (0.43) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 | |
| SCHEMBL9118750 | 0.69 | MAOB (0.47) | PDE5AMAPK14P2RY12 | |
| SCHEMBL31501813 | 0.69 | MAPT (0.51) | NPC1RAB9AMAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079637-B1 | ANTI-SRS-A CARBOXYLIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL FORMULATION CONTAINING THEM | FISONS plc (GB) | 1987-01-28 | — | — | EP | disclosed |
| US-4474788-A | Anti-SRSA quinoline carboxylic acid derivatives | FISONS PLC (GB) | 1984-10-02 | — | — | US | disclosed |
| EP-0079637-A1 | Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them | FISONS plc (GB) | 1983-05-25 | — | — | EP | disclosed |