Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | RHEB | Q15382 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | CTSV | O60911 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10809218 | 0.83 | NPC1 (0.42) | PDE5AFFAR4PIK3CGCTSVCTSL | |
| SCHEMBL10812031 | 0.81 | FFAR4 (0.44) | PDE5AFFAR4BRD4KDM4EALDH1A1 | |
| SCHEMBL10810642 | 0.78 | KDM4E (0.41) | PDE5AFFAR4KDM4EALDH1A1POLB | |
| SCHEMBL10808457 | 0.78 | KDM4E (0.41) | PDE5AFFAR4KDM4EALDH1A1POLB | |
| SCHEMBL10972035 | 0.70 | PDE5A (0.52) | PDE5AKDM4EALDH1A1POLBMAPT | |
| SCHEMBL10972521 | 0.69 | PDE5A (0.55) | PDE5AFFAR4MAPTFFAR1PPARG | |
| SCHEMBL9118750 | 0.69 | MAOB (0.47) | PDE5ALMNAPPARGPPARDPPARA | |
| SCHEMBL23512775 | 0.69 | POLB (0.56) | RHEBBRD4ALDH1A1POLBMAPT | |
| SCHEMBL71120 | 0.68 | GSTP1 (0.44) | RHEBPOLBMAPTLMNAPPARG | |
| SCHEMBL10974265 | 0.68 | PDE5A (0.53) | PDE5AKDM4EALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079637-B1 | ANTI-SRS-A CARBOXYLIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION, AND PHARMACEUTICAL FORMULATION CONTAINING THEM | FISONS plc (GB) | 1987-01-28 | — | — | EP | disclosed |
| US-4474788-A | Anti-SRSA quinoline carboxylic acid derivatives | FISONS PLC (GB) | 1984-10-02 | — | — | US | disclosed |
| EP-0079637-A1 | Anti-srs-a carboxylic acid derivatives, processes for their production, and pharmaceutical formulation containing them | FISONS plc (GB) | 1983-05-25 | — | — | EP | disclosed |