Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAPDH | P04406 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497926 | 0.95 | NPSR1 (0.76) | NPSR1ALDH1A1LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL2513419 | 0.94 | NPSR1 (0.64) | NPSR1ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL10847185 | 0.92 | NPSR1 (0.56) | NPSR1ALDH1A1MAPTLMNAMAPK1 | |
| SCHEMBL31582321 | 0.80 | NPSR1 (1.00) | NPSR1ALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL2830170 | 0.80 | NPSR1 (1.00) | NPSR1ALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL2501529 | 0.80 | NPSR1 (0.83) | NPSR1ALDH1A1LMNAHPGDPOLB | |
| SCHEMBL10812615 | 0.79 | NPSR1 (0.70) | NPSR1ALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL2499562 | 0.78 | NPSR1 (0.73) | NPSR1ALDH1A1MAPTLMNAHPGD | |
| SCHEMBL4546890 | 0.78 | RAB9A (0.55) | ALDH1A1L3MBTL1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL10810550 | 0.76 | NPSR1 (0.53) | NPSR1KDM4EMEN1KMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088593-B1 | 1,2,4-TRIAZINE AND PYRAZINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1987-05-27 | — | — | EP | disclosed |
| US-4585861-A | ACTIVATORS OF GAMMA-AMINOBUTYRIC ACID AND BENZODIAZEPINE BINDING | ELI LILLY AND COMPANY (US) | 1986-04-29 | — | — | US | disclosed |
| US-4513135-A | GAMMA-AMINOBUTYRIC ACID BINDING AGTIVATORS | ELI LILLY AND COMPANY (US) | 1985-04-23 | — | — | US | disclosed |
| EP-0088593-A2 | 1,2,4-Triazine and pyrazine derivatives | ELI LILLY AND COMPANY (US) | 1983-09-14 | — | — | EP | disclosed |