Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10635085 | 0.80 | AKR1C3 (0.54) | ALDH1A1TDP1MAPK1MAPTHPGD | |
| SCHEMBL10635096 | 0.78 | ERN1 (0.47) | L3MBTL1ALDH1A1TDP1MAPK1MAPT | |
| SCHEMBL7990043 | 0.77 | ALDH1A1 (0.57) | HCAR3L3MBTL1ALDH1A1TDP1MAPK1 | |
| SCHEMBL30615538 | 0.76 | ABCG2 (0.49) | L3MBTL1ALDH1A1TDP1MAPK1CASP7 | |
| SCHEMBL21463999 | 0.76 | ABCG2 (0.49) | L3MBTL1ALDH1A1TDP1MAPK1CASP7 | |
| SCHEMBL3996405 | 0.76 | ALDH1A1 (0.58) | HCAR3L3MBTL1ALDH1A1TDP1MAPK1 | |
| SCHEMBL6179431 | 0.76 | AKR1C3 (0.74) | HCAR3L3MBTL1ALDH1A1TDP1MAPK1 | |
| SCHEMBL4944345 | 0.76 | L3MBTL1 (0.60) | L3MBTL1ALDH1A1TDP1MAPK1CASP7 | |
| SCHEMBL9943157 | 0.74 | L3MBTL1 (0.70) | HCAR3L3MBTL1ALDH1A1TDP1MAPK1 | |
| SCHEMBL7976555 | 0.74 | TDP1 (0.54) | HCAR3L3MBTL1ALDH1A1TDP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4698430-A | ANTIDEPRESSANT | A. H. ROBINS COMPANY, INC. (US) | 1987-10-06 | — | — | US | disclosed |
| US-4558132-A | ANTIDEPRESSANTS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1985-12-10 | — | — | US | disclosed |
| EP-0099614-A2 | Nitro, amino and aroylamino-N-phenylpyridinamines and their use in a process for preparing pyrido(1,4)benzodiazapines | A.H. ROBINS COMPANY, INCORPORATED (US) | 1984-02-01 | — | — | EP | disclosed |