Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.44 |
| ▸ | ZDHHC20 | Q5W0Z9 | 3/20 | 0.43 |
| ▸ | ZDHHC2 | Q9UIJ5 | 2/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13314415 | 1.00 | PAOX (0.57) | PAOXAPEX1SLC6A5ZDHHC20ZDHHC2 | |
| SCHEMBL111589 | 0.98 | PAOX (0.53) | PAOXAPEX1SLC6A5ZDHHC20ZDHHC2 | |
| SCHEMBL21049693 | 0.92 | PAOX (0.45) | PAOXAPEX1SLC6A5ZDHHC20ZDHHC2 | |
| SCHEMBL111174 | 0.92 | PAOX (0.45) | PAOXAPEX1SLC6A5ZDHHC20ZDHHC2 | |
| SCHEMBL22187118 | 0.90 | APEX1 (0.51) | APEX1ZDHHC20ZDHHC2EGFRKDM4E | |
| SCHEMBL109850 | 0.84 | — | — | |
| SCHEMBL21049696 | 0.84 | — | — | |
| SCHEMBL21610956 | 0.83 | APEX1 (0.49) | APEX1ZDHHC20ZDHHC2EGFRKDM4E | |
| SCHEMBL25582746 | 0.83 | PAOX (0.60) | PAOXSLC6A5ZDHHC20ZDHHC2GNAI3 | |
| SCHEMBL13314418 | 0.82 | APEX1 (0.47) | APEX1ZDHHC20ZDHHC2EGFRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130196434-A1 | ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND | ALNYLAM PHARMACEUTICALS, INC. (US) | 2013-08-01 | — | — | US | disclosed |
| EP-2424491-A2 | FILM FORMER IN HAIR DYES | Henkel AG & Co. KGaA (DE) | 2012-03-07 | — | — | EP | disclosed |
| US-20110223665-A1 | ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND | ALNYLAM PHARMACEUTICALS, INC. (US) | 2011-09-15 | — | — | US | disclosed |
| US-20110130440-A1 | NON-NATURAL RIBONUCLEOTIDES, AND METHODS OF USE THEREOF | ALNYLAM PHARMACEUTICALS, INC. (US) | 2011-06-02 | — | — | US | disclosed |
| WO-2010124897-A2 | FILM FORMER IN HAIR DYES | HENKEL AG & CO. KGAA (DE) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130440-A1 | NON-NATURAL RIBONUCLEOTIDES, AND METHODS OF USE THEREOF | NSUN2, RNMT, RNGTT | PAOX 2632/4885APEX1 137/4885SLC6A5 2945/4885 |
| US-20130196434-A1 | ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND | NSUN2, SNRPE, RNASE1 | PAOX 4088/4885APEX1 83/4885SLC6A5 2156/4885 |
| US-20110223665-A1 | ENHANCEMENT OF siRNA SILENCING ACTIVITY USING UNIVERSAL BASES OR MISMATCHES IN THE SENSE STRAND | NSUN2, SNRPE, RNASE1 | PAOX 4088/4885APEX1 83/4885SLC6A5 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.