SCHEMBL1082236

SCHEMBL1082236

CCC(Cc1cccc(NC(=O)C(c2ccc(CN3N=C(c4ccccc4)OCC3=O)cc2)C(C)C)c1)C(=O)O

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ACKR3 P25106 1/20 0.39
PARP1 P09874 2/20 0.39
MAOB P27338 2/20 0.36
ITGB3 P05106 7/20 0.36
ITGA2B P08514 7/20 0.36
PLA2G10 O15496 1/20 0.35
PLA2G2A P14555 1/20 0.35
FFAR2 O15552 1/20 0.35
BACE1 P56817 1/20 0.34
HDAC1 Q13547 2/20 0.34
TP53 P04637 1/20 0.34
MAPT P10636 1/20 0.34
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
TSHR P16473 1/20 0.34
TTK P33981 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1081661 0.95 PARP1 (0.45) ACKR3PARP1MAOBITGB3ITGA2B
SCHEMBL3693016 0.93 PARP1 (0.40) ACKR3PARP1MAOBITGB3ITGA2B
SCHEMBL1082041 0.92 MAOB (0.38) MAOBITGB3ITGA2BFFAR2BACE1
SCHEMBL1193806 0.87 PTGES (0.42) ACKR3PARP1MAOBITGB3ITGA2B
SCHEMBL1079856 0.87 PTGES (0.45) ACKR3MAOBMAPT
SCHEMBL1178122 0.86 ACKR3 (0.40) ACKR3PARP1MAOBITGB3ITGA2B
SCHEMBL1082238 0.85 ITGB3 (0.40) ACKR3PARP1MAOBITGB3ITGA2B
SCHEMBL1177676 0.84 MAOB (0.37) ACKR3PARP1MAOBITGB3ITGA2B
SCHEMBL3693615 0.84 ITGB3 (0.36) ACKR3PARP1MAOBITGB3ITGA2B
SCHEMBL1178412 0.84 ACKR3 (0.39) ACKR3PARP1MAOBITGB3ITGA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2268625-B1 OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF Bayer Pharma AG (DE) 2012-05-16 EP disclosed
EP-2268625-A1 OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF Bayer Schering Pharma Aktiengesellschaft (DE) 2011-01-05 EP disclosed
WO-2009127338-A1 OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2009-10-22 WO disclosed