SCHEMBL3693016

SCHEMBL3693016

CCCC(C)C(C(=O)Nc1cccc(CC(CC)C(=O)O)c1)c1ccc(CN2N=C(c3ccccc3)OCC2=O)cc1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 2/20 0.40
MAOB P27338 2/20 0.35
ITGB3 P05106 8/20 0.34
ITGA2B P08514 8/20 0.34
MME P08473 1/20 0.33
PLA2G10 O15496 1/20 0.33
PLA2G2A P14555 1/20 0.33
ACKR3 P25106 1/20 0.33
PPARG P37231 2/20 0.33
PPARD Q03181 2/20 0.33
PPARA Q07869 2/20 0.33
TSHR P16473 1/20 0.32
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32
PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1081661 0.95 PARP1 (0.45) PARP1MAOBITGB3ITGA2BMME
SCHEMBL1082236 0.93 ACKR3 (0.39) PARP1MAOBITGB3ITGA2BPLA2G10
SCHEMBL1178364 0.89 PTGES (0.40) PARP1MAOBITGB3ITGA2BACKR3
SCHEMBL1178155 0.85 ITGB3 (0.39) PARP1MAOBITGB3ITGA2B
SCHEMBL1082041 0.85 MAOB (0.38) MAOBITGB3ITGA2BPPARGPPARD
SCHEMBL1079856 0.84 PTGES (0.45) MAOBACKR3MAPT
SCHEMBL1178371 0.84 PARP1 (0.44) PARP1MAOBITGB3ITGA2BACKR3
SCHEMBL1068094 0.84 PARP1 (0.45) PARP1MAOBITGB3ITGA2BACKR3
SCHEMBL3696073 0.83 MAOB (0.40) PARP1MAOBITGB3ITGA2BACKR3
SCHEMBL1178391 0.82 PARP1 (0.43) PARP1MAOBITGB3ITGA2BACKR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2268625-B1 OXO-HETEROCYCLIC SUBSTITUTED CARBOXYLIC ACID DERIVATES AND THE USE THEREOF Bayer Pharma AG (DE) 2012-05-16 EP disclosed