SCHEMBL10822902

SCHEMBL10822902

Cc1ccc([CH]C(C)Cl)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.44
RAB9A P51151 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
NPC1 O15118 1/20 0.42
TDP1 Q9NUW8 2/20 0.41
MAPT P10636 2/20 0.41
KDM4E B2RXH2 1/20 0.41
POLB P06746 1/20 0.41
RECQL P46063 1/20 0.41
MDM2 Q00987 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
ACHE P22303 1/20 0.40
NFE2L2 Q16236 2/20 0.39
RELA Q04206 1/20 0.37
CA1 P00915 1/20 0.37
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
FBP1 P09467 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9824054 0.79 CYP2A6 (0.48) CYP2A6RAB9ASMN1; SMN2NPC1TDP1
SCHEMBL3336700 0.77 HTR2A (0.39) CYP2A6L3MBTL1RELAMAOB
SCHEMBL16932229 0.75 CYP2A6 (0.44) CYP2A6RAB9ASMN1; SMN2NPC1TDP1
P-Xylene SCHEMBL11301004 0.74 ACHE (0.61) CYP2A6SMN1; SMN2TDP1ACHECA1
SCHEMBL5063720 0.73 CYP2A6 (0.42) CYP2A6RAB9ASMN1; SMN2NPC1TDP1
P-Xylene SCHEMBL17784277 0.71 ACHE (0.67) CYP2A6SMN1; SMN2TDP1ACHECA1
SCHEMBL22163763 0.70 CYP2A6 (0.44) CYP2A6RAB9ASMN1; SMN2NPC1TDP1
SCHEMBL27908207 0.68 NFE2L2 (0.43) CYP2A6RAB9ASMN1; SMN2NPC1TDP1
P-Xylene SCHEMBL2589553 0.68 ACHE (0.61) CYP2A6SMN1; SMN2TDP1ACHECA1
SCHEMBL28247099 0.67

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0089769-B1 9-SUBSTITUTED CARBACYCLIN ANALOGUES THE UPJOHN COMPANY (US) 1986-10-01 EP disclosed
EP-0092352-B1 9-SUBSTITUTED CARBACYCLINS THE UPJOHN COMPANY (US) 1986-07-02 EP disclosed
EP-0086611-B1 9-SUBSTITUTED CARBACYCLIN ANALOGUES THE UPJOHN COMPANY (US) 1986-05-21 EP disclosed
US-4588823-A 9-substituted carbacyclin analogs THE UPJOHN COMPANY (US) 1986-05-13 US disclosed
US-4585886-A 9-Substituted carbacyclin analogs THE UPJOHN COMPANY (US) 1986-04-29 US disclosed
US-4490555-A 9-Substituted carbacyclin analogs THE UPJOHN COMPANY (US) 1984-12-25 US disclosed
US-4487961-A ANTIULCER, ANTIASTHMA, ANTICOAGULANTS THE UPJOHN COMPANY (US) 1984-12-11 US disclosed
US-4487960-A 9-Substituted carbacyclin analogs THE UPJOHN COMPANY (US) 1984-12-11 US disclosed
EP-0092352-A1 9-Substituted carbacyclins THE UPJOHN COMPANY (US) 1983-10-26 EP disclosed
EP-0089769-A1 9-Substituted carbacyclin analogues THE UPJOHN COMPANY (US) 1983-09-28 EP disclosed
EP-0088619-A2 Benzopyrans THE UPJOHN COMPANY (US) 1983-09-14 EP disclosed
US-4401824-A Benzopyran compounds, derivatives of prostaglandins THE UPJOHN COMPANY (US) 1983-08-30 US disclosed
EP-0086611-A1 9-Substituted carbacyclin analogues THE UPJOHN COMPANY (US) 1983-08-24 EP disclosed