Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 5/20 | 0.68 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786081 | 0.84 | MAPT (0.64) | ESRRAMAPTSMN1; SMN2RAB9AHPGD | |
| SCHEMBL11511159 | 0.81 | MAPT (0.60) | ESRRAMAPTRAB9AHPGDLMNA | |
| SCHEMBL10825749 | 0.78 | HPGD (0.56) | ESRRAMAPTSMN1; SMN2RAB9AHPGD | |
| SCHEMBL10825715 | 0.77 | ESRRA (0.52) | ESRRAFFAR1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL4543869 | 0.77 | ESR1 (0.57) | ESRRAMAPTSMN1; SMN2RAB9AHPGD | |
| SCHEMBL9619575 | 0.77 | ESR1 (0.57) | ESRRAMAPTSMN1; SMN2RAB9AHPGD | |
| SCHEMBL822859 | 0.76 | MAPT (0.57) | ESRRAMAPTHPGDLMNAMEN1 | |
| SCHEMBL11564627 | 0.76 | ESRRA (0.61) | ESRRAFFAR1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL1284188 | 0.76 | MAPT (0.54) | ESRRAFFAR1MAPTHPGDMAOB | |
| SCHEMBL10964527 | 0.76 | ESRRA (0.56) | ESRRAFFAR1MAPTSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4592876-A | Arylglyoxals | AMERICAN CYANAMID COMPANY (US) | 1986-06-03 | — | — | US | disclosed |
| US-4474810-A | HYPOGLYCEMIC AGENTS, ANTIDIABETIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0114389-A2 | Substituted arylglyoxal derivatives | AMERICAN CYANAMID COMPANY (US) | 1984-08-01 | — | — | EP | disclosed |
| US-4168385-A | LOWERING OF STEROL AND TRIGLYCERIDE SERUM LEVELS | AMERICAN CYANAMID COMPANY (US) | 1979-09-18 | — | — | US | disclosed |
| US-4125729-A | Hypolipemic α-aryloxy para substituted phenyl acetic acid compounds | AMERICAN CYANAMID COMPANY (US) | 1978-11-14 | — | — | US | disclosed |